Sun LJ, Lu JX, Li XY, Zheng TS, Zhan XR. Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance. World J Diabetes 2023; 14(10): 1514-1523 [PMID: 37970127 DOI: 10.4239/wjd.v14.i10.1514]
Corresponding Author of This Article
Xiao-Rong Zhan, MD, Chief Doctor, Professor, Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, No. 199 Dazhi Street, Nangang District, Harbin 150001, Heilongjiang Province, China. xiaorongzhandoctor@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Li-Jie Sun, Ji-Xuan Lu, Xin-Yu Li, Xiao-Rong Zhan, Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Tian-Sheng Zheng, Xiao-Rong Zhan, Department of Endocrinology, Southern University of Science and Technology Hospital, Shenzhen 518071, Guangdong Province, China
Author contributions: Zhan XR conceived and designed the study; Sun LJ, Lu JX, Li XY, and Zheng TS collected the data; Sun LJ and Zhan XR analyzed the findings; Sun LJ and Lu JX wrote the manuscript; and all authors revised and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Ethical Committees of the First Affiliated Hospital of Harbin Medical University.
Informed consent statement: All patient data obtained, recorded, and managed only used for this study, and all patient information are strictly confidential, without any harm to the patient, so the informed consent was waived by the Ethics Committee of First Affiliated Hospital of Harbin Medical University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Rong Zhan, MD, Chief Doctor, Professor, Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, No. 199 Dazhi Street, Nangang District, Harbin 150001, Heilongjiang Province, China. xiaorongzhandoctor@126.com
Received: June 20, 2023 Peer-review started: June 20, 2023 First decision: July 7, 2023 Revised: July 19, 2023 Accepted: August 15, 2023 Article in press: August 15, 2023 Published online: October 15, 2023 Processing time: 111 Days and 3.9 Hours
Core Tip
Core Tip: A retrospective analysis was conducted on 162 type 2 diabetes mellitus (T2DM) patients to analyze the risk factor for insulin resistance (IR) and to investigate the effects of vitamin D supplementation on glucose and lipid metabolism in patients with T2DM and IR. It was found that 25-hydroxyvitamin D3 and body mass index were risk factors for IR in T2DM patients, and vitamin D supplementation improved the glucose and lipid metabolism in patients with IR. The treatment regimen with vitamin D supplementation led to more significant decreases in 2-h postprandial blood glucose, fasting blood glucose, glycosylated hemoglobin, triglyceride, and total cholesterol levels and more increase in high-density lipoprotein-cholesterol than the conventional regimen. It is suggested that vitamin D supplementation may be an effective intervention for T2DM patients with vitamin D deficiency and IR.
