Clinical Trials Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2021; 12(3): 278-291
Published online Mar 15, 2021. doi: 10.4239/wjd.v12.i3.278
Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity
Gui-Ying Guo, Li-Juan Zhang, Biao Li, Rong-Bin Liang, Qian-Min Ge, Hui-Ye Shu, Qiu-Yu Li, Yi-Cong Pan, Chong-Gang Pei, Yi Shao
Gui-Ying Guo, Li-Juan Zhang, Biao Li, Rong-Bin Liang, Qian-Min Ge, Hui-Ye Shu, Qiu-Yu Li, Yi-Cong Pan, Chong-Gang Pei, Yi Shao, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Guo GY was involved in the data curation and writing of the original draft; Zhang LJ performed the data curation and formal analysis, and participated in the writing and editing of the manuscript; Li B was involved in the data curation, and writing, review, and editing of the manuscript; Liang RB took part in the data curation and supervision of the study; Ge QM was involved in the study conceptualization and methodology design; Shu HY was involved in data validation and visualization; Li QY participated in the methodology design and data visualization; Pan YC was involved in methodology design and data validation; Shao Y and Pei CG were involved in the study conceptualization, data curation, funding acquisition, and project administration; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81660158 and No. 81400372; Natural Science Research Foundation of Jiangxi Province, No. 20161ACB21017; and Medical Science Foundation of Jiangxi Province, No. 20181BBG70004 and No. 20164017.
Institutional review board statement: This study is in line with the principles specified by the Declaration of Helsinki. Before asking subjects to sign an informed consent form, we explained the purpose of the study and the possible risks in detail. The protocol was approved by the Medical Ethics Committee of the First Affiliated Hospital of Nanchang University (No. 2015029).
Clinical trial registration statement: This study is registered at Medical Ethics Committee of the First Affiliated Hospital of Nanchang University. The registration identification number is JX2015029.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: This is not an industry supported study. The authors report no conflicts of interest in this work.
Data sharing statement: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
CONSORT 2010 statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Shao, MD, Professor, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. freebee99@163.com
Received: November 20, 2020
Peer-review started: November 20, 2020
First decision: December 24, 2020
Revised: December 30, 2020
Accepted: February 11, 2021
Article in press: February 11, 2021
Published online: March 15, 2021
Processing time: 101 Days and 23.6 Hours
Core Tip

Core Tip: Through the analysis of resting state functional magnetic resonance imaging, combined with the statistical calculation of all data, this study aimed to understand altered spontaneous brain activity in patients with diabetic optic neuropathy, and find out the differences of regional homogeneity values in different brain regions as well as the correlation of other clinical related behaviors, so as to guide the diagnosis and prevention of diabetes optic neuropathy.