©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2021; 12(11): 1894-1907
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1894
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1894
p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus
Ting-Ting Huang, Cheeloo College of Medicine, Shandong University, Jinan 250000, Shandong Province, China
Ting-Ting Huang, Hong-Li Ma, Department of Obstetrics, Taian City Central Hospital, Taian 271000, Shandong Province, China
Wen-Juan Sun, Department of Obstetrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250000, Shandong Province, China
Hai-Ying Liu, Department of Obstetrics and Gynecology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266000, Shandong Province, China
Bao-Xia Cui, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, Shandong Province, China
Author contributions: Huang TT, Sun WJ, Liu HY, and Cui BX designed and coordinated the study; Huang TT, Sun WJ, and Ma HL performed the experiments, acquired, and analyzed the data; Huang TT, Sun WJ, and Liu HY interpreted the data; Huang TT and Sun WJ wrote the manuscript; All authors approved the final version of the article.
Supported by The Scientific Research Fund of Qilu Hospital (Qingdao) , No. QDKY2015ZD04 .
Institutional review board statement: The study was reviewed and approved by the Taian City Central Hospital Institutional Review Board (Approval NO. 2016-05-15).
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at cuibaoxia@sdu.edu.cn. Participants gave informed consent for data sharing.
Corresponding author: Bao-Xia Cui, PhD, Chief Physician, Professor, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan 250013, Shandong Province, China. cuibaoxia@sdu.edu.cn
Received: July 22, 2021
Peer-review started: July 22, 2021
First decision: August 16, 2021
Revised: August 29, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 15, 2021
Processing time: 116 Days and 5.6 Hours
Peer-review started: July 22, 2021
First decision: August 16, 2021
Revised: August 29, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 15, 2021
Processing time: 116 Days and 5.6 Hours
Core Tip
Core Tip: The role of placental mitochondria in the etiology of gestational diabetes mellitus (GDM) is an emerging area of research. In this study, we report the expression levels of dynamin-related protein 1 (Drp1) and p66Shc in GDM and in the JEG3 human trophoblast cell line. Increased expression of p66Shc was induced by high glucose-activated Drp1 and promoted overproduction of reactive oxygen species, which may be the primary cause of cell damage and apoptosis during the occurrence and development of GDM.