Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2020; 11(6): 252-260
Published online Jun 15, 2020. doi: 10.4239/wjd.v11.i6.252
Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?
Wen-Chi Wu, Wei-Jei Lee, Tzong-His Lee, Shu-Chun Chen, Chih-Yen Chen
Wen-Chi Wu, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan
Wei-Jei Lee, Department of Surgery, Min-Sheng General Hospital, Taoyuan 330, Taiwan
Wei-Jei Lee, Taiwan Society for Metabolic and Bariatric Surgery, Taipei 11031, Taiwan
Tzong-His Lee, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
Shu-Chun Chen, Department of Nursing, Chang-Gung Institute of Technology, Guishan, Taoyuan 333, Taiwan
Chih-Yen Chen, Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan
Chih-Yen Chen, Faculty of Medicine and Institute of Emergency and Critical Medicine, National Yang-Ming University School of Medicine, Taipei 11221, Taiwan
Chih-Yen Chen, Association for the Study of Small Intestinal Diseases, Guishan, Taoyuan 33305, Taiwan
Chih-Yen Chen, Chinese Taipei Society for the Study of Obesity, Taipei 110, Taiwan
Author contributions: Wu WC and Lee TH contributed equally to this work and should be regarded as co-first authors. Chen CY conceived and designed the study and did data-analysis and patient data collection; Lee WJ performed bariatric surgery and collected the data of the patients; Wu WC reviewed the literature and wrote the original draft of the manuscript; Chen CY, Lee WJ, Lee TH, Chen SC, and Wu WC made critical revisions and approved the final version of the manuscript.
Supported by grants from Min-Sheng General Hospital, Taoyuan, and Far Eastern Memorial Hospital-National Yang-Ming University Joint Research Program, No. 105DN15, No. 106DN15, and No. 107DN14 to Lee TH and Chen CY.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of National Yang-Ming University.
Clinical trial registration statement: This is a clinical observation, not a clinical trial.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no potential conflicts of interest to declare.
Data sharing statement: The statistical code and dataset are available from the corresponding author at chency@vghtpe.gov.tw.
CONSORT 2010 statement: This is a clinical observation, not a clinical trial. This manuscript was exempted from the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chih-Yen Chen, AGAF, MD, PhD, Attending Doctor, Professor, Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei 11217, Taiwan. chency@vghtpe.gov.tw
Received: December 31, 2019
Peer-review started: December 31, 2019
First decision: March 24, 2020
Revised: April 9, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: June 15, 2020
Processing time: 153 Days and 23.4 Hours
Core Tip

Core tip: Bariatric surgery is a very effective strategy for managing obesity patients and those with type 2 diabetes mellitus. Matrix metalloproteinases play roles in extracellular matrix remodeling which consequently results in insulin resistance. Some authors reported higher levels of matrix metalloproteinases (MMP)-2, -7, and -9 in obese or diabetic patients. We measured plasma MMP-2, -7, and -9 concentrations in obese patients before and after bariatric surgeries; however, we did not identify any statistical differences in the MMP levels. We suggested that bariatric surgery reduces obesity and diabetes through MMP-2, -7, or -9 independent pathways.