Agarkov AA, Popova TN, Boltysheva YG. Influence of 10-(6-plastoquinonyl) decyltriphenylphosphonium on free-radical homeostasis in the heart and blood serum of rats with streptozotocin-induced hyperglycemia. World J Diabetes 2019; 10(12): 546-559 [PMID: 31915517 DOI: 10.4239/wjd.v10.i12.546]
Corresponding Author of This Article
Aleksandr A Agarkov, PhD, Assistant Professor, Department of Medical Biochemistry and Microbiology, Voronezh State University, 1 Universitetskaya pl., Voronezh 394018, Russia. agalalek@mail.ru
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Dec 15, 2019; 10(12): 546-559 Published online Dec 15, 2019. doi: 10.4239/wjd.v10.i12.546
Influence of 10-(6-plastoquinonyl) decyltriphenylphosphonium on free-radical homeostasis in the heart and blood serum of rats with streptozotocin-induced hyperglycemia
Aleksander A Agarkov, Tatyana N Popova, Yana G Boltysheva
Aleksander A Agarkov, Tatyana N Popova, Yana G Boltysheva, Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh 394018, Russia
Author contributions: Popova TN and Agarkov AA participated equally in designed and coordinated the research and performed the majority of experiments and analyzed the data, wrote the paper; Boltysheva YG performed the molecular investigations and participated in treatment of animals.
Institutional review board statement: The results of the study were reviewed meeting of the Scientific and Technical Council Voronezh State University.
Institutional animal care and use committee statement: The results of the study were reviewed at a meeting of the Ethical Review Committee for Biomedical Research of the Voronezh State University.
Conflict-of-interest statement: Potential conflicts of interest not detected.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Aleksandr A Agarkov, PhD, Assistant Professor, Department of Medical Biochemistry and Microbiology, Voronezh State University, 1 Universitetskaya pl., Voronezh 394018, Russia. agalalek@mail.ru
Received: July 26, 2019 Peer-review started: July 26, 2019 First decision: August 19, 2019 Revised: October 20, 2019 Accepted: October 27, 2019 Article in press: October 27, 2019 Published online: December 15, 2019 Processing time: 143 Days and 5.2 Hours
Core Tip
Core tip: The results of this research suggest that the mitochondria targeted antioxidant 10-(6-plastoquinonyl) decyltriphenylphosphonium (SkQ1) might be a potential substance for incorporation into the antioxidant therapy of type 2 diabetes mellitus. The ability of this compound to lower the intensity of free-radical processes, acting as the key component of the pathogenesis of the type 2 diabetes mellitus, serves as the basis for this conclusion. Thus, after the introduction of SkQ1 to the animals with streptozotocin induced hyperglycemia, the values of the biochemiluminescence parameters reflecting the free-radical oxidation intensity, the concentration of diene conjugates and carbonyl products of protein oxidation, aconitate hydratase activity, and citrate content approached those of control values. At the same time, the activity level of the antioxidant enzymes superoxide dismutase and catalase approached those of normal values.
