Sana SRGL, Chen GM, Lv Y, Guo L, Li EY. Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus. World J Diabetes 2022; 13(10): 888-899 [PMID: 36312001 DOI: 10.4239/wjd.v13.i10.888]
Corresponding Author of This Article
En-You Li, PhD, Doctor, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Clinical Trials Study
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Sana SRGL, Chen GM, Lv Y, Guo L, Li EY. Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus. World J Diabetes 2022; 13(10): 888-899 [PMID: 36312001 DOI: 10.4239/wjd.v13.i10.888]
World J Diabetes. Oct 15, 2022; 13(10): 888-899 Published online Oct 15, 2022. doi: 10.4239/wjd.v13.i10.888
Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Sana SRGL, Chen GM, Lv Y, Guo L, and Li EY designed the research study; Sana SRGL, Chen GM, Lv Y, and Guo L performed the research, and contributed new reagents and analytic tools; Sana SRGL analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.
Clinical trial registration statement: This study is registered with the Chinese Clinical Trial Registry (No. ChiCTR2000038703).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at lienyou_1111@163.com.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Corresponding author: En-You Li, PhD, Doctor, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com
Received: June 18, 2022 Peer-review started: June 18, 2022 First decision: July 14, 2022 Revised: July 23, 2022 Accepted: September 12, 2022 Article in press: September 12, 2022 Published online: October 15, 2022 Processing time: 117 Days and 18.8 Hours
ARTICLE HIGHLIGHTS
Research background
Gestational diabetes mellitus (GDM) is a metabolic disorder in which hyperglycemia develops during pregnancy in non-diabetic women.
Research motivation
Gas chromatography-mass spectrometry (GC-MS) was used to analyze changes in metabonomics in pregnant women with GDM and to explore the mechanism of cognitive function decline in pregnant women with GDM.
Research objectives
To study the cognitive function of pregnant women with GDM and to identify potential volatile markers to evaluate the cognitive impairment of pregnant women with GDM.
Research methods
Solid-phase microextraction GC-MS analysis was used to detect organic matter in plasma and urine samples. The statistical methods used were principal component analysis and partial least squares-discriminant analysis.
Research results
Differential volatile metabolites in the serum of pregnant women with GDM mainly included hexanal, 2-octen-1-ol, and 2-propanol. The differential volatile metabolites in the urine of pregnant women with GDM included benzene, cyclohexanone, 1-hexanol, and phenol.
Research conclusions
Of 2-propanol may be a potential volatile marker to evaluate the cognitive impairment of pregnant women with GDM.
Research perspectives
The study of perinatal cognitive decline is worthwhile, especially in women with GDM. The key is the prevention and treatment of the disease. Whether 2-propanol can be used as a therapeutic target requires further investigation.
