Sana SRGL, Chen GM, Lv Y, Guo L, Li EY. Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus. World J Diabetes 2022; 13(10): 888-899 [PMID: 36312001 DOI: 10.4239/wjd.v13.i10.888]
Corresponding Author of This Article
En-You Li, PhD, Doctor, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Clinical Trials Study
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Sana SRGL, Chen GM, Lv Y, Guo L, Li EY. Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus. World J Diabetes 2022; 13(10): 888-899 [PMID: 36312001 DOI: 10.4239/wjd.v13.i10.888]
World J Diabetes. Oct 15, 2022; 13(10): 888-899 Published online Oct 15, 2022. doi: 10.4239/wjd.v13.i10.888
Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Sana SRGL, Chen GM, Lv Y, Guo L, and Li EY designed the research study; Sana SRGL, Chen GM, Lv Y, and Guo L performed the research, and contributed new reagents and analytic tools; Sana SRGL analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.
Clinical trial registration statement: This study is registered with the Chinese Clinical Trial Registry (No. ChiCTR2000038703).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at lienyou_1111@163.com.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Corresponding author: En-You Li, PhD, Doctor, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com
Received: June 18, 2022 Peer-review started: June 18, 2022 First decision: July 14, 2022 Revised: July 23, 2022 Accepted: September 12, 2022 Article in press: September 12, 2022 Published online: October 15, 2022 Processing time: 117 Days and 18.8 Hours
Abstract
BACKGROUND
Gestational diabetes mellitus (GDM) is a metabolic disease with an increasing annual incidence rate. Our previous observational study found that pregnant women with GDM had mild cognitive decline.
AIM
To analyze the changes in metabonomics in pregnant women with GDM and explore the mechanism of cognitive function decline.
METHODS
Thirty GDM patients and 30 healthy pregnant women were analyzed. Solid-phase microextraction gas chromatography/mass spectrometry was used to detect organic matter in plasma and urine samples. Statistical analyses were conducted using principal component analysis and partial least squares discriminant analysis.
RESULTS
Differential volatile metabolites in the serum of pregnant women with GDM included hexanal, 2-octen-1-ol, and 2-propanol. Differential volatile metabolites in the urine of these women included benzene, cyclohexanone, 1-hexanol, and phenol. Among the differential metabolites, the conversion of 2-propanol to acetone may further produce methylglyoxal. Therefore, 2-propanol may be a potential marker for serum methylglyoxal.
CONCLUSION
2-propanol may be a potential volatile marker to evaluate cognitive impairment in pregnant women with GDM.
Core Tip: Gas chromatography-mass spectrometry was used in a metabonomics analysis to determine the changes in volatile metabolites in pregnant women with gestational diabetes mellitus (GDM) and to explore the mechanism of cognitive function decline in these women. 2-propanol was identified as a potential volatile marker to evaluate cognitive impairment in pregnant women with GDM.
