Mazidi M, Rezaie P, Jangjoo A, Tavassoli A, Rajabi MT, Kengne AP, Nematy M. Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients. World J Diabetes 2017; 8(7): 374-380 [PMID: 28751961 DOI: 10.4239/wjd.v8.i7.374]
Corresponding Author of This Article
Mohsen Nematy, Associate Professor, Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Daneshgah St., Mashhad 91388, Iran. nematym@mums.ac.ir
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jul 15, 2017; 8(7): 374-380 Published online Jul 15, 2017. doi: 10.4239/wjd.v8.i7.374
Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients
Mohsen Mazidi, Peyman Rezaie, Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Andre Pascal Kengne, Mohsen Nematy
Mohsen Mazidi, Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100049, China
Mohsen Mazidi, Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing 100049, China
Peyman Rezaie, Mohsen Nematy, Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad 91388, Iran
Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Department of Surgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad 91388, Iran
Andre Pascal Kengne, Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town 7501, South Africa
Author contributions: All authors contributed to the manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohsen Nematy, Associate Professor, Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Daneshgah St., Mashhad 91388, Iran. nematym@mums.ac.ir
Telephone: +98-511-8002103 Fax: +98-511-8002421
Received: November 14, 2016 Peer-review started: November 14, 2016 First decision: December 1, 2016 Revised: February 5, 2017 Accepted: June 6, 2017 Article in press: June 7, 2017 Published online: July 15, 2017 Processing time: 230 Days and 23.2 Hours
Abstract
AIM
To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity.
METHODS
This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year.
RESULTS
Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m2 between baseline and 12-mo follow-up, while mean fat mass decreased by 45.9% from 64.2 kg to 34.7 kg. An improvement was also observed in the gluco-metabolic profile with both fasting glucose and HbA1c substantially decreasing (P < 0.001).
CONCLUSION
The present study shows the short to medium term (1 year) health benefits of bariatric surgery for patients of Middle Eastern ethnicity.
Core tip: The present study obviously shows the health benefits of Roux-en-Y gastric bypass bariatric surgery for the patients of Middle Eastern ethnicity, particularly during the first twelve months of follow-up.
