Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.707
Peer-review started: August 30, 2014
First decision: December 17, 2014
Revised: December 30, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 10, 2015
Processing time: 295 Days and 15.6 Hours
The co-occurrence of celiac disease (CD) and type 1 diabetes (T1DM) has been reported as 5-7 times more prevalent than CD alone. The clinical presentation and natural history of CD in patients with T1DM may vary considerably. Less than 10% of patients with T1DM and CD show gastrointestinal symptoms. Therefore, experts support screening for CD in T1DM patients, though there is no consensus as to the recommended frequency of screening. When stratified by time since CD diagnosis, longer follow-up and coexistence of CD are associated with significant increased risk of diabetic associated morbidity and mortality. Early CD diagnosis and treatment with a gluten-free diet are essential.
Core tip: Increased prevalence rates of celiac disease (CD) are described among individuals with type 1 diabetes mellitus (T1DM). Specifically celiac disease is more prevalent in females with T1DM. Less than 10% of patients with T1DM and CD show gastrointestinal symptoms therefore screening is necessary. The significant increase of diabetic associated morbidity and mortality, emphasize the importance of early diagnosis of CD and appropriate treatment with gluten-free diet.