Is there a role for platelet indices in predicting poor glucoregulation in type 2 diabetes mellitus?

Abstract

In this editorial, we discuss the recent article by Regassa et al, published in the World Journal of Diabetes, which highlights the potential role of platelet indices (PI) in predicting poor glucoregulation in patients with type 2 diabetes mellitus (T2DM). Given the high morbidity and mortality associated with T2DM, there is a constant need to find new and accessible methods for predicting and treating individuals with this condition. The pathophysiology of T2DM involves systemic inflammation, metabolic dysfunction, and an increased risk of vascular injury, which are commonly associated with the development of microvascular and macrovascular complications, such as cardiovascular diseases and neuropathies. The link between these complications and T2DM requires further elucidation but may be explained by prolonged exposure to high glycemic levels and increased advanced glycation end products. PI might play an important role in determining whether some individuals are prone to poor glucoregulation. Recent evidence encourages the scientific efforts to demonstrate the consistency of this role and its applicability in monitoring glucoregulation, underscoring the importance of the study by Regassa et al.

Keywords: Platelet indices; Platelet count; Type 2 diabetes mellitus; Adult; Glycemic Control; Diabetes complications; Inflammation mediators

Core Tip: This editorial discusses the role of platelet indices (PI) such as platelet count, mean platelet volume, plateletcrit, platelet large cell ratio, and platelet distribution width as potential predictors of poor glucoregulation in type 2 diabetes mellitus (T2DM). Emerging evidence shows that elevated PI levels correlate with inadequate glucoregulation and microvascular complications. Incorporating PI into routine assessments may offer a cost-effective tool for predicting glycemic outcomes in patients with T2DM, especially in resource-limited settings.