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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Interdisciplinary perspectives on diabetes and microcirculatory dysfunction: A global bibliometric analysis
Yuan Li, Bing Wang, Meng-Ting Xu, Ying-Yu Wang, Wei-Qi Liu, Sun-Jing Fu, Bing-Wei Li, Hao Ling, Xue-Ting Liu, Xiao-Yan Zhang, Ai-Ling Li, Xu Zhang, Ming-Ming Liu
Yuan Li, Bing Wang, Meng-Ting Xu, Ying-Yu Wang, Wei-Qi Liu, Sun-Jing Fu, Bing-Wei Li, Xue-Ting Liu, Xiao-Yan Zhang, Ai-Ling Li, Ming-Ming Liu, Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
Yuan Li, Bing Wang, Meng-Ting Xu, Ying-Yu Wang, Wei-Qi Liu, Sun-Jing Fu, Bing-Wei Li, Xue-Ting Liu, Xiao-Yan Zhang, Ai-Ling Li, Ming-Ming Liu, International Center of Microvascular Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
Hao Ling, Department of Radiology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, Hunan Province, China
Xu Zhang, Laboratory of Electron Microscopy, Ultrastructural Pathology Center, Peking University First Hospital, Beijing 100034, China
Ming-Ming Liu, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
Author contributions: Liu MM conceived and designed the study; Li Y performed the publications search; Li Y, Fu SJ, Wang YY, and Xu MT browsed and excluded the duplicate documents; Li Y, Wang B, and Ling H browsed and excluded the documents that did not meet the inclusion criteria; Li Y, Liu XT, Zhang XY, Liu WQ, Zhang X, and Li AL participated in the data analysis; Li Y, Li BW, and Liu MM performed the data visualization; Li Y and Liu MM prepared the manuscript; Liu MM edited the manuscript; all authors revised and approved the final manuscript.
Supported by Beijing Municipal Natural Science Foundation, China, No. 7212068; and National Natural Science Foundation of China, No. 81900747.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Ming-Ming Liu, PhD, Research Scientist, Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 5 Dong Dan Third Alley, Dongcheng District, Beijing 100005, China.
mingmingliu@imc.pumc.edu.cn
Received: May 28, 2024
Revised: October 24, 2024
Accepted: December 2, 2024
Published online: February 15, 2025
Processing time: 216 Days and 0.1 Hours
BACKGROUND
The prevalence of diabetes and its association with microcirculatory dysfunction presents a significant challenge in contemporary global health. Addressing this nexus is crucial for developing targeted therapeutic interventions.
AIM
To trace the progression and delineate the current state of interdisciplinary research concerning diabetes and microcirculation.
METHODS
Employing a bibliometric approach, this study scrutinizes 12886 peer-reviewed publications retrieved from the PubMed and Web of Science databases. The focus is on elucidating the research trajectory and thematic concentrations at the confluence of diabetes and microcirculation.
RESULTS
Research outputs have surged since 2011, with the United States, China, and the United Kingdom leading in the quantity and quality of publications. This analysis revealed that journals such as Diabetes Care and The New England Journal of Medicine, along with top research institutions, have significantly contributed to advancing the understanding of microvascular processes affected by diabetes. The central themes identified include inflammation, oxidative stress, and endothelial dysfunction, which are critical in mediating the microvascular complications of diabetes.
CONCLUSION
This bibliometric evaluation reveals an evolving landscape focusing on diabetes and microcirculatory dysfunction. The complexity of diabetic microvascular issues encouraged multidisciplinary research strategies that are imperative for global health outcomes.
Core Tip: This bibliometric analysis elucidates the relationship between diabetes and microcirculation, spotlighting the central role of endothelial dysfunction in the pathophysiology of diabetes-related complications. Leveraging extensive datasets from PubMed and Web of Science Core Collection, our study traces the evolution of research from the foundational studies of the 1950s to contemporary explorations into microvascular responses under diabetic conditions. It reveals that endothelial disruption, influenced by oxidative stress and inflammatory pathways, significantly contributes to the microvascular complications prevalent in diabetes. The research reveals the need for advancements in non-invasive diagnostic technologies and targeted therapeutic strategies that address the microvascular aspects of diabetes.
