Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.154
Peer-review started: November 5, 2023
First decision: December 6, 2023
Revised: December 16, 2023
Accepted: January 19, 2024
Article in press: January 19, 2024
Published online: February 15, 2024
Processing time: 90 Days and 19 Hours
Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic islet β-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorate diabetic complications, particularly those of vascular origin. In the present review, we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.
Core Tip: At present, a compelling body of evidence suggests that dietary polyphenols may represent an important alternative source to the management of type 2 diabetes mellitus due to their multifaceted actions on glucose homeostasis as well as in attenuating many diabetes complications raised because of the hyperglycemic condition. Additionally, new data derived from either clinical trials or meta-analyses have started to figure out the usefulness of these bioactive compounds thus providing solid clinical shreds of evidence.