Cao YH, Zhou YM, Wang SY, Guo J, Cen LS. Promise of the gut microbiota in prevention and traditional Chinese medicine treatment of diabetic peripheral neuropathy. World J Diabetes 2024; 15(12): 2387-2393 [DOI: 10.4239/wjd.v15.i12.2387]
Corresponding Author of This Article
Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yuan-Hao Cao, Yi-Mai Zhou, Si-Yu Wang, The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Jing Guo, Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang Province, China
Lu-Sha Cen, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang Province, China
Author contributions: Cao YH designed the overall concept and outline of the manuscript; Cao YH, Zhou YM and Wang SY contributed to manuscript writing and review of literature; Guo J and Cen LS contributed to conceptualization and supervision. All authors have read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 82104862; Scientific Research Project Foundation of Zhejiang Chinese Medical University, No. 2023FSYYZZ01 and No. 2023RCZXZK49; and Scientific Research Project Foundation of Zhejiang Association of Rehabilitation Medicine, No. ZKKY2024018.
Conflict-of-interest statement: All authors disclosed no relevant relationships.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Received: July 21, 2024 Revised: September 22, 2024 Accepted: October 12, 2024 Published online: December 15, 2024 Processing time: 119 Days and 17.3 Hours
Abstract
The pathogenesis of diabetic peripheral neuropathy (DPN) has not been fully elucidated, and treatment options are limited. Currently, the main strategies for treating DPN are strict glycemic control and symptomatic pain relief. In this editorial, we comment on an article by Li et al, which suggested that modulating the gut microbiota using traditional Chinese medicine (TCM) may be a promising strategy for alleviating DPN symptoms. The regulation of the gut microbiota has received widespread attention in the study of various diseases. TCM can participate in the regulation of gut microbiota through multiple mechanisms, and this regulatory effect can alleviate the clinical symptoms of DPN. We briefly analyzed the promise of the gut microbiota in the early diagnosis, treatment, and clinical efficacy of TCM for DPN. The gut microbiota has potential value at multiple nodes in the occurrence and progression of DPN.
Core Tip: Associations have been observed between gut microbiota and diabetic peripheral neuropathy (DPN). Traditional Chinese medicine (TCM) alleviates the clinical symptoms of DPN through complex interactions with gut microbiota. This editorial briefly summarized the present condition of the treatment of DPN and discusses the potential applications of gut microbiota in the prevention and treatment of DPN, such as early diagnosis, studying of the mechanism of TCM, and evaluating the clinical efficacy of TCM.
