Chen LH, Ran XW. Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers. World J Diabetes 2024; 15(12): 2384-2386 [DOI: 10.4239/wjd.v15.i12.2384]
Corresponding Author of This Article
Xing-Wu Ran, MD, Chief Physician, Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. ranxingwu@163.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Dec 15, 2024; 15(12): 2384-2386 Published online Dec 15, 2024. doi: 10.4239/wjd.v15.i12.2384
Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers
Li-Hong Chen, Xing-Wu Ran
Li-Hong Chen, Xing-Wu Ran, Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Li-Hong Chen, Xing-Wu Ran, Innovation Research Center for Diabetic Foot, Diabetic Foot Care Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Chen LH and Ran XW made significant contribution to this manuscript, including the conceptualization and outline of the study, discussion and design of the research, writing and editing of the manuscript, as well as literature review; all authors critically reviewed and approved the final version of the paper.
Supported by the Health Commission of Sichuan Province, No. 23LCYJ042; the Science and Technology Bureau of Sichuan Province, No. 2021JDKP004; and a Research Grant Investigating the Effect and Mechanism of Secretory Components Derived from Umbilical Cord Mesenchymal Stem Cells on Chronic Wound Healing in Bama Miniature Pig with Diabetes, No. HX-H2206155.
Conflict-of-interest statement: The authors have nothing to declare for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xing-Wu Ran, MD, Chief Physician, Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. ranxingwu@163.com
Received: July 15, 2024 Revised: September 18, 2024 Accepted: October 22, 2024 Published online: December 15, 2024 Processing time: 125 Days and 4.5 Hours
Abstract
In this paper, we provide a commentary on an article focusing on diabetic foot ulcer (DFU) as a dreadful complication of diabetes mellitus. The development of this condition is influenced by factors such as diabetic peripheral neuropathy, lower extremity artery disease, and infection. However, the underlying mechanism remains elusive. Macrophages play a critical role in wound healing processes, suggesting that therapies targeting these cells could potentially improve the management of DFU. A comprehensive understanding of developmental trends of macrophages within the field of DFU may facilitate research advancements and the development of novel treatment strategies.
Core Tip: Macrophages play a pivotal role in the intricate process of wound healing. Advancements in macrophage research pertaining to diabetic foot ulcer (DFU) hold immense potential for augmenting and expediting the wound healing process associated with DFU.
