Fan MW, Tian JL, Chen T, Zhang C, Liu XR, Zhao ZJ, Zhang SH, Chen Y. Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications. World J Diabetes 2024; 15(10): 2041-2057 [PMID: 39493568 DOI: 10.4239/wjd.v15.i10.2041]
Corresponding Author of This Article
Yan Chen, PhD, Professor, Department of Gastroenterology, Binzhou Medical University Hospital, No. 661 Yellow River Second Road, Bincheng District, Binzhou 256600, Shandong Province, China. chenyanfeihong0906@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Oct 15, 2024; 15(10): 2041-2057 Published online Oct 15, 2024. doi: 10.4239/wjd.v15.i10.2041
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications
Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen
Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen, Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Co-first authors: Ming-Wei Fan and Jin-Lan Tian.
Co-corresponding authors: Shu-Hui Zhang and Yan Chen.
Author contributions: Fan MW and Tian JL contributed equally to this study as they are co-first authors of this manuscript. Fan MW, Zhang SH, and Chen Y discussed the data; Tian JL, Chen T, Zhang C, Liu XR, and Zhao ZJ drafted the manuscript and also took responsibility of the data analysis. Zhang SH and Chen Y contributed equally to this study as they are co- corresponding authors of this manuscript.
Supported bythe Natural Science Foundation of Shandong Province, No. ZR2022MH153; and “Clinical + X” Project Fund of Binzhou Medical College, No. BY2021LCX11.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Chen, PhD, Professor, Department of Gastroenterology, Binzhou Medical University Hospital, No. 661 Yellow River Second Road, Bincheng District, Binzhou 256600, Shandong Province, China. chenyanfeihong0906@163.com
Received: May 18, 2024 Revised: August 14, 2024 Accepted: August 26, 2024 Published online: October 15, 2024 Processing time: 131 Days and 6.1 Hours
Abstract
Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.
Core Tip: Inflammation mediated by the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is closely related to the occurrence and development of diabetes and its complications. This article focuses on the specific mechanism of cGAS-STING signaling pathway in mediating inflammatory response as well as the role of cGAS-STING signaling in complications such as diabetes, diabetic gastroenteropathy, diabetic cardiomyopathy, and non-alcoholic fatty liver disease, along with the role of transmission pathways and the related research progress.
