Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.758
Peer-review started: February 28, 2023
First decision: March 14, 2023
Revised: March 25, 2023
Accepted: April 24, 2023
Article in press: April 24, 2023
Published online: June 15, 2023
Processing time: 106 Days and 22.6 Hours
The global burden of diabetic foot ulcers (DFUs) is a significant public health concern, affecting millions of people worldwide. These wounds cause considerable suffering and have a high economic cost. Therefore, there is a need for effective strategies to prevent and treat DFUs. One promising therapeutic approach is the use of adiponectin, a hormone primarily produced and secreted by adipose tissue. Adiponectin has demonstrated anti-inflammatory and anti-atherogenic properties, and researchers have suggested its potential therapeutic applications in the treatment of DFUs. Studies have indicated that adiponectin can inhibit the production of pro-inflammatory cytokines, increase the production of vascular endothelial growth factor, a key mediator of angiogenesis, and inhibit the activation of the intrinsic apoptotic pathway. Additionally, adiponectin has been found to possess antioxidant properties and impact glucose metabolism, the immune system, extracellular matrix remodeling, and nerve function. The objective of this review is to summarize the current state of research on the potential role of adiponectin in the treatment of DFUs and to identify areas where further research is needed in order to fully understand the effects of adiponectin on DFUs and to establish its safety and efficacy as a treatment for DFUs in the clinical setting. This will provide a deeper understanding of the underlying mechanisms of DFUs that can aid in the development of new and more effective treatment strategies.
Core Tip: The global burden of diabetic foot ulcers (DFUs) is significant, both in terms of human suffering and healthcare costs. Therefore, effective strategies to prevent and treat DFUs are urgently needed. Adiponectin, a hormone produced by adipose tissue, shows promise as a therapeutic option for DFUs due to its anti-inflammatory, antioxidant, and pro-angiogenic effects. While adiponectin has potential therapeutic applications, further research is necessary to establish its safety and efficacy in clinical settings. This review aims to summarize current research on adiponectin’s potential role in treating DFUs and identify areas requiring further investigation.