Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.741
Peer-review started: January 3, 2023
First decision: January 17, 2023
Revised: February 24, 2023
Accepted: April 11, 2023
Article in press: April 11, 2023
Published online: June 15, 2023
Processing time: 163 Days and 3.2 Hours
Diabetic neuropathy (DN) is a devastating disorder with an increasing prevalence globally. This epidemic can pose a critical burden on individuals and com-munities, subsequently affecting the productivity and economic output of a country. With more people living a sedentary lifestyle, the incidence of DN is escalating worldwide. Many researchers have relentlessly worked on ways to combat this devastating disease. Their efforts have given rise to a number of commercially available therapies that can alleviate the symptoms of DN. Unfortunately, most of these therapies are only partially effective. Worse still, some are associated with unfavorable side effects. This narrative review aims to highlight current issues and challenges in the management of DN, especially from the perspective of molecular mechanisms that lead to its progression, with the hope of providing future direction in the management of DN. To improve the approaches to diabetic management, the suggested resolutions in the literature are also discussed in this review. This review will provide an in-depth understanding of the causative mechanisms of DN, apart from the insights to improve the quality and strategic approaches to DN management.
Core Tip: This review elaborates on the current aspects regarding diabetic neuropathy (DN), especially issues pertaining to the treatments and current challenges in the management of DN with some suggested recommendations on strategies to slow down DN progression. In order to increase the understanding of DN, current lines of therapy, the understanding of its pathophysiology, and future direction of its management are also included. Perhaps, this review may provide insights to understand the important information regarding DN and give ideas for improvement of treatments and management of DN.