Role of nutritional ketosis in the improvement of metabolic parameters following bariatric surgery

Abstract

BACKGROUND

Ketone bodies (KB) might act as potential metabolic modulators besides serving as energy substrates. Bariatric metabolic surgery (BMS) offers a unique opportunity to study nutritional ketosis, as acute postoperative caloric restriction leads to increased lipolysis and circulating free fatty acids.

AIM

To characterize the relationship between KB production, weight loss (WL) and metabolic changes following BMS.

METHODS

For this retrospective study we enrolled male and female subjects aged 18-65 years who underwent BMS at a single Institution. Data on demographics, anthropometrics, body composition, laboratory values and urinary KB were collected.

RESULTS

Thirty-nine patients had data available for analyses [74.4% women, mean age 46.5 ± 9.0 years, median body mass index 41.0 (38.5; 45.4) kg/m², fat mass 45.2% ± 6.2%, 23.1% had diabetes, 43.6% arterial hypertension and 74.4% liver steatosis]. At 46.0 ± 13.6 d post-surgery, subjects had lost 12.0% ± 3.6% of pre-operative weight. Sixty-nine percent developed ketonuria. Those with nutritional ketosis were significantly younger [42.9 (37.6; 50.7) years vs 51.9 (48.3; 59.9) years, P = 0.018], and had significantly lower fasting glucose [89.5 (82.5; 96.3) mg/dL vs 96.0 (91.0; 105.3) mg/dL, P = 0.025] and triglyceride levels [108.0 (84.5; 152.5) mg/dL vs 152.0 (124.0; 186.0) mg/dL, P = 0.045] vs those with ketosis. At 6 mo, percent WL was greater in those with postoperative ketosis (-27.5% ± 5.1% vs 23.8% ± 4.3%, P = 0.035). Urinary KBs correlated with percent WL at 6 and 12 mo. Other metabolic changes were similar.

CONCLUSION

Our data support the hypothesis that subjects with worse metabolic status have reduced ketogenic capacity and, thereby, exhibit a lower WL following BMS.

Keywords: Obesity; Ketone bodies; Bariatric surgery; Weight loss; Glucose metabolism; Lipid metabolism

Core Tip: Ketone bodies might act as potential metabolic modulators besides serving as energy substrates. Acute postoperative caloric and carbohydrate restriction after bariatric metabolic surgery (BMS) leads to increased lipolysis, inducing ketogenesis. We report that the majority, but not all patients undergoing BMS, develop nutritional ketosis. Patients with nutritional ketosis had significantly lower baseline fasting glucose and triglyceride levels vs those without ketonuria. Weight loss was greater in those with postoperative ketonuria, and urinary ketones positively correlated with percent weight loss. These observations suggest that subjects with worse glucometabolic status have reduced ketogenic capacity, which might blunt the metabolic response to BMS.