Editorial
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2020; 11(4): 95-99
Published online Apr 15, 2020. doi: 10.4239/wjd.v11.i4.95
Age of onset of diabetes and all-cause mortality
Gary Yee Ang
Gary Yee Ang, Health Services and Outcomes Research, National Healthcare Group, Singapore 138543, Singapore
Author contributions: GY Ang wrote the review based on literature and was responsible for drafting and final approval of the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with author in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Gary Yee Ang, MBBS, Doctor, Associate Consultant, Health Services and Outcomes Research, National Healthcare Group, Fusionopolis 3, Singapore 138543, Singapore. gary_ang@nhg.com.sg
Received: December 23, 2019
Peer-review started: December 23, 2019
First decision: January 29, 2020
Revised: February 19, 2020
Accepted: February 23, 2020
Article in press: February 23, 2020
Published online: April 15, 2020
Processing time: 105 Days and 1.5 Hours
Abstract

Diabetes mellitus continues to present a large social, financial and health system burden across the world. The relationship between age of onset of the different types of diabetes and all-cause mortality is uncertain. In this review paper, the relationship between age of onset of the different types of diabetes and all-cause mortality will be reviewed and an update of the current evidence will be presented. There is strong evidence of the relationship between age of onset of type 2 diabetes mellitus (T2DM) and all-cause mortality, good evidence of the relationship between age of onset of T1DM and all-cause mortality and no evidence of the relationship between age of onset of gestational diabetes or prediabetes and all-cause mortality. Further research is needed to look at whether aggressive management of earlier onset of T2DM can help to reduce premature mortality.

Keywords: Diabetes mellitus; Age of onset; Mortality; Type 1 diabetes; Type 2 diabetes; Gestational diabetes; Prediabetes

Core tip: In this review paper we will look at the relationship between age of onset of the different types of diabetes (type 1 diabetes mellitus, type 2 diabetes mellitus, gestational and prediabetes) and all-cause mortality and provides an update of the current evidence.