Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology

Table 1 Tumor-infiltrating lymphocytes associated with the prognosis of gastric cancer

Ref.	Sample size	Patient group	Location	Criteria (cut-off)	Prognostic role
Kang et al[15]	120	EBVaGC	Stromal	High infiltration	Decreased DFS and RFS
Grogg et al[16]	110	G	Intratumoral	High infiltration	Increased CSS
Lee et al[17]	220	G	Intratumoral	High density	Increased OS

EBVaGC: Epstein-Barr virus-associated gastric cancer; DFS: Disease-free survival; RFS: Recurrence-free survival; G: Gastric cancer; CSS: Cancer-specific survival; OS: Overall-survival.

Table 2 Lymphocyte subtypes associated with the prognosis of gastric cancer

Ref.	Lymphocyte subtypes	Sample size	Patient group	Criteria (cut-off)	Prognostic role
Lee et al[17]	CD3+, CD8+, CD45RO+	220	G	High density	Increased OS
Thompson et al[18]	CD8+	43	G/GEJ	High density	Decreased PFS and OS
Kawazoe et al[33]	CD8+	487	G	High density	Increased OS
Wakatsuki et al[30]	CD45RO+	101	G	High numbers	Increased PFS and OS
Chiaravalli et al[34]	CD3+, CD8+	96	MSI-H G	High numbers	Increased OS
Kim et al[22]	CD8+, FOXP3+	99	MSI-H G	High density	Increased OS
Liu et al[23]	CD8+/FOXP3+ ratio	166	G	High ratio	Increased OS
Shen et al[26]	FOXP3+/CD8+ ratio	133	G	High ratio	Decreased OS
Wang et al[5]	FOXP3+	107	G	High expression	Increased OS
Haas et al[20]	FOXP3+	52	G	High numbers	Increased OS
Mizukami et al[24]	FOXP3+	120	G	Diffuse pattern	Decreased OS
Perrone et al[25]	FOXP3+	110	G	High numbers	Decreased RFS and OS
Zhou et al[27]	FOXP3+	133	G	High numbers	Decreased OS
Choi et al[19]	FOXP3+/CD4+ ratio	28	G	High ratio	Increased OS
Kim et al[21]	FOXP3+/CD4+ ratio	180	G	High ratio	Decreased OS
Dong et al[35]	CD20+	100	G	High density	Increased OS
Ishigami et al[31]	NK cells	146	G	High numbers	Increased OS
Rosso et al[36]	NK cells	72	G	High concentration	Increased DFS and OS
Ishigami et al[37]	NK cells	169	G	High numbers	Increased OS
Ubukata et al[28]	Th1/Th2 ratio	157	G	High ratio1	Increased OS
Liu et al[29]	Th22, Th17	32	G	High numbers1	Decreased OS

¹Peripheral blood. G: Gastric cancer; OS: Overall-survival; G/GEJ: Gastric/gastro-esophageal junction cancer; PFS: Progression-free survival; MSI-H: Microsatellite instability-high; RFS: Relapse-free survival; DFS: Disease-free survival.