Association of uterine artery Doppler, follicle-stimulating hormone, and anti-Müllerian hormone with post-chemotherapy ovarian reserve in reproductive-age colorectal cancer patients

Table 1 Comparison of general characteristics between the two groups, n (%)/mean ± SD

Indicator	Diminished ovarian reserve group (n = 50)	Normal ovarian reserve group (n = 60)	χ2/t	P value
Age, years			0.478	0.489
< 35	16 (32.00)	23 (38.33)
≥ 35	34 (68.00)	37 (61.67)
BMI (kg/m2)	23.26 ± 2.17	23.54 ± 2.36	0.638	0.525
Menarche age, years	12.94 ± 2.56	13.28 ± 2.55	0.703	0.484
Gravidity, times	1.28 ± 0.70	1.53 ± 0.70	1.888	0.062
Menstrual cycle, days	30.30 ± 1.63	29.88 ± 2.10	-1.144	0.255
History of ovarian surgery			-	0.687
No	47 (94.00)	56 (93.33)
Yes	3 (6.00)	4 (6.67)
Disease duration, years	2.12 ± 0.44	2.22 ± 0.52	1.057	0.293
Tumor diameter, cm	2.98 ± 0.57	3.06 ± 0.80	0.629	0.531
Type of chemotherapy			0.178	0.673
Non platinum containing scheme	10 (20.00)	14 (23.33)
Platinum containing scheme	40 (80.00)	46 (76.67)
Tumor staging			0.079	0.779
I-II	27 (54.00)	34 (56.67)
III-IV	23 (46.00)	26 (43.33)
Smoking or not			-	0.753
No	46 (92.00)	54 (90.00)
Yes	4 (8.00)	6 (10.00)
Drinking or not			-	0.726
No	47 (94.00)	55 (91.67)
Yes	3 (6.00)	5 (8.33)

BMI: Body mass index.

Table 2 Comparison of uterine artery ultrasound hemodynamic parameters between the two groups after chemotherapy, n (%)/mean ± SD

Group	n	PI	RI	PSV (cm/second)
Diminished ovarian reserve group	50	2.56 ± 0.28	0.91 ± 0.06	33.62 ± 3.26
Normal ovarian reserve group	60	2.28 ± 0.36	0.83 ± 0.11	37.45 ± 3.29
t value		-4.469	-5.061	6.101
P value		< 0.001	< 0.001	< 0.001

PI: Pulsatility index; RI: Resistance index; PSV: Peak systolic velocity.

Table 3 Comparison of follicle-stimulating hormone and anti-Müllerian hormone levels between the two groups after chemotherapy (mean ± SD)

Group	n	FSH (mIU/mL)	AMH (ng/mL)
Diminished ovarian reserve group	50	10.27 ± 2.95	1.92 ± 0.24
Normal ovarian reserve group	60	8.20 ± 2.13	3.29 ± 1.18
t value		-4.128	8.798
P value		< 0.001	< 0.001

FSH: Follicle-stimulating hormone; AMH: Anti-Müllerian hormone.

Table 4 Predictive value of uterine artery ultrasound hemodynamic parameters, follicle-stimulating hormone and anti-Müllerian hormone levels for diminished ovarian reserve function

Indicator	AUC	P value	Sensitivity (%)	Specificity (%)	Accuracy (%)	95%CI
PI	0.726	< 0.001	0.88 (44/50)	0.50 (30/60)	67.27 (74/110)	0.632-0.819
RI	0.733	< 0.001	0.90 (45/50)	0.52 (31/60)	69.09 (76/110)	0.640-0.825
PSV	0.791	< 0.001	0.92 (46/50)	0.52 (31/60)	70.00 (77/110)	0.708-0.873
FSH	0.723	< 0.001	0.62 (31/50)	0.82 (49/60)	72.73 (80/110)	0.622-0.824
AMH	0.895	< 0.001	0.94 (47/50)	0.85 (51/60)	89.09 (98/110)	0.823-0.966
Combined detection	0.950	< 0.001	0.94 (47/50)	0.90 (54/60)	91.82 (101/110)	0.911-0.989

FSH: Follicle-stimulating hormone; AMH: Anti-Müllerian hormone; PI: Pulsatility index; RI: Resistance index; PSV: Peak systolic velocity; AUC: Area under the curve.