Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120985
Published online Aug 15, 2026. doi: 10.4251/wjgo.v18.i8.120985
Published online Aug 15, 2026. doi: 10.4251/wjgo.v18.i8.120985
Association of uterine artery Doppler, follicle-stimulating hormone, and anti-Müllerian hormone with post-chemotherapy ovarian reserve in reproductive-age colorectal cancer patients
Chun-Ya Chen, Lin-Ling Tan, Jun-Yi Zhang, Department of Ultrasonic Medicine, Yuyao Maternal and Child Health Hospital, Ningbo 315400, Zhejiang Province, China
Ya-Ping Zhang, Department of Oncology, The Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou 311200, Zhejiang Province, China
Author contributions: Chen CY participated in research design and data collection; Tan LL is responsible for data analysis and paper writing; Zhang JY participated in research design and data analysis; Zhang YP is responsible for fund application, data analysis, review and editing, communication and coordination, ethical review, copyright and license and follow-up; and all authors have read and accepted the final manuscript.
AI contribution statement: AI tools (specifically Grammarly and DeepL) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Institutional review board statement: The research was reviewed and approved by the Yuyao Maternal and Child Health Hospital, No. YFYLS-2026-001.
Informed consent statement: The requirement for written informed consent was waived by the Ethics Committee because of the retrospective nature of the study.
Conflict-of-interest statement: No conflict of interest is associated with this work.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No other data available.
Corresponding author: Ya-Ping Zhang, Associate Chief Physician, Department of Oncology, The Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728 Yucai North Road, Xiaoshan District, Hangzhou 311200, Zhejiang Province, China. fuyou_chun2025@163.com
Received: March 17, 2026
Revised: March 30, 2026
Accepted: May 7, 2026
Published online: August 15, 2026
Processing time: 142 Days and 17.1 Hours
Revised: March 30, 2026
Accepted: May 7, 2026
Published online: August 15, 2026
Processing time: 142 Days and 17.1 Hours
Core Tip
Core Tip: Combined assessment of uterine artery Doppler parameters [pulsatility index (PI), resistance index (RI), and peak systolic velocity (PSV)] with serum follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) levels demonstrates superior predictive value for diminished ovarian reserve in reproductive-aged colorectal cancer patients after chemotherapy. The combined detection achieved an area under the curve of 0.950, significantly outperforming any single indicator, with PI, RI, and FSH positively correlated, while PSV and AMH negatively correlated with ovarian reserve decline. This multimodal approach provides a non-invasive, comprehensive strategy for early identification of che