Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma

doi:10.4251/wjgo.120942

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120942
Published online Aug 15, 2026. doi: 10.4251/wjgo.120942

Table 1 Correlation between the tumor regression grade and post-neoadjuvant chemotherapy TP53 circulating tumor DNA status, n (%)

Variables	Total (n = 9)	TRG 1 (n = 2)	TRG 2 (n = 4)	TRG 3 (n = 3)	P value
Post-NCT TP53 ctDNA					0.012
-	6 (66.67)	2 (100.00)	4 (100.00)	0 (0.00)
+	3 (33.33)	0 (0.00)	0 (0.00)	3 (100.00)

TRG: Tumor regression grade; NCT: Neoadjuvant chemotherapy; ctDNA: Circulating tumor DNA.

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Citation: Gu RT, Liu T, Piao ZS, Jin H, Wang XW, Li X. Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; 18(8): 120942
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/120942.htm
DOI: https://dx.doi.org/10.4251/wjgo.120942

Gu RT, Liu T, Piao ZS, Jin H, Wang XW, Li X. Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; 18(8): 120942 [DOI: 10.4251/wjgo.120942]

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