IGF2BP1 promotes gastric cancer progression by stabilizing HS6ST2 mRNA in an N6-methyladenosine-dependent manner

doi:10.4251/wjgo.119282

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 119282
Published online Jul 15, 2026. doi: 10.4251/wjgo.119282

Table 1 Correlation of insulin-like growth factor 2 mRNA-binding protein expression with clinicopathological parameters in patients with gastric cancer (n = 72), n (%)

Variables	Cases (n)	IGF2BP1 expression		P value
Variables	Cases (n)	Low	High	P value
Age in years				0.303
≥ 60	37	5 (13.5)	32 (86.5)
< 60	35	8 (22.9)	27 (77.1)
Sex				0.017^a
Male	48	5 (10.4)	43 (89.6)
Female	24	8 (33.3)	16 (66.7)
Pathological stage				0.759
I/II	36	7 (19.4)	29 (80.6)
III/IV	36	6 (16.7)	30 (83.3)
Lymph node metastasis				0.013^a
No	19	7 (36.8)	12 (63.2)
Yes	53	6 (11.3)	47 (88.7)

^aP < 0.05.

The χ² test was used to assess associations between insulin-like growth factor 2 mRNA-binding protein 1 expression levels and clinicopathological variables. IGF2BP: Insulin-like growth factor 2 mRNA-binding protein.

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Citation: Liu L, Zhou YJ, Xu Y, Yin QQ, Wang JJ, Xu SJ, Yan LL, Wang ZZ, Li SW, Mao XL, Zhang Y. IGF2BP1 promotes gastric cancer progression by stabilizing HS6ST2 mRNA in an N6-methyladenosine-dependent manner. World J Gastrointest Oncol 2026; 18(7): 119282
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/119282.htm
DOI: https://dx.doi.org/10.4251/wjgo.119282

Liu L, Zhou YJ, Xu Y, Yin QQ, Wang JJ, Xu SJ, Yan LL, Wang ZZ, Li SW, Mao XL, Zhang Y. IGF2BP1 promotes gastric cancer progression by stabilizing HS6ST2 mRNA in an N6-methyladenosine-dependent manner. World J Gastrointest Oncol 2026; 18(7): 119282 [DOI: 10.4251/wjgo.119282]

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