Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report

doi:10.4251/wjgo.117886

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 117886
Published online Jul 15, 2026. doi: 10.4251/wjgo.117886

Table 1 Top five up-regulated and down-regulated differentially expressed genes identified by comparing tumor tissue with matched adjacent normal tissue

Ref. gene	Chr	FPKM	LogFC	Start	End	Regulation
RN7SL1	14	94314.6	2.21133344022303	49586580	49586878	Up
RN7SL5P	9	22974.06	3.33884426000912	9442060	9442380	Up
MUC6	11	4825.41	1.85533269177306	1012823	1036718	Up
PGC	6	4119.34	1.30674514409015	41736711	41754109	Up
RNU5B-1	15	3756.98	1.03904869573663	65296051	65296166	Up
MT-CO2	MT	4780.26	-2.605230914	7586	8269	Down
MT-CO1	MT	4370.38	-2.551138358	5904	7445	Down
MT-ND1	MT	4170.04	-2.860642759	3307	4262	Down
MT-ND4	MT	3861.51	-3.112439091	10760	12137	Down
MT-CO3	MT	3663.65	-2.559351762	9207	9990	Down

Chr: Chromosome; FC: Fold change; FPKM: Fragments per kilobase of transcript sequence per million mapped fragments; MT: Mitochondrial chromosome; Ref: Reference.

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Citation: Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; 18(7): 117886
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/117886.htm
DOI: https://dx.doi.org/10.4251/wjgo.117886

Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; 18(7): 117886 [DOI: 10.4251/wjgo.117886]

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