Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma

doi:10.4251/wjgo.v18.i4.116821

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Apr 15, 2026 (publication date) through Apr 11, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Apr 15, 2026; 18(4): 116821
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116821

Table 1 Clinical/general information of the subjects

Group	n	Gender (male/female)	Age (year; median)
Health control	52	1.36:1 (30/22)	39.0
Virus hepatitis	55	1:0.90 (26/29)	49.0
Non-virus hepatitis	85	1.83:1 (55/30)	43.0
Liver cirrhosis	102	2.52:1 (73/29)	43.5
HCC	138	4.52:1 (113/25)	61.0
HCC patients after radical resection	93	2.88:1 (69/24)	62.0
HCC recurrence	26	3.33:1 (20/6)	64.0
χ²		29.265
P value		< 0.001

HCC: Hepatocellular carcinoma.

Full Size Table

Table 2 Comparison of serum chitinase-3-like protein 1 levels in liver diseases patients

Group	Group serum CHI3L1 level (ng/mL)
Group	25^th percentile	50^th percentile	75^th percentile
Health control	36.79	40.99	51.47
Virus hepatitis	36.81	58.91	85.39
Non-virus hepatitis	34.50	50.89	77.34
Liver cirrhosis	61.58	100.13	161.38^a^,^b^,^c
HCC	67.38	141.07	271.77^a^,^b^,^c
HCC patients after radical resection	32.77	64.27	130.78^d^,^e
HCC recurrence	35.09	156.00	554.6^a^,^b^,^c

^aP < 0.001 vs health control.

^bP < 0.001 vs virus hepatitis.

^cP < 0.001 vs non-virus hepatitis.

^dP < 0.05 vs liver cirrhosis.

^eP < 0.05 vs hepatocellular carcinoma.

CHI3L1: Chitinase-3-like protein 1; HCC: Hepatocellular carcinoma.

Full Size Table

Citation: Zhang HY, Zhang RL, Jia YY, Liu Y, Zhu L, Liu F, Rao HY. Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116821
URL: https://www.wjgnet.com/1948-5204/full/v18/i4/116821.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i4.116821