Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study

doi:10.4251/wjgo.v17.i4.97644

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 97644
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.97644

Table 1 Correlation between Snail family transcriptional repressor 1 expression and clinicopathological parameters of 26 esophageal cancer patients

Clinicopathological factor	High (n = 13)	Low (n = 13)	χ²	P value
Gender
Male	10	11	0.2476	0.6188
Female	3	2	0.2476	0.6188
Age
< 70	10	13	3.391	0.0655
≥ 70	3	0	3.391	0.0655
Differentiation
Well and moderately	6	10	2.6	0.1069
Poorly	7	3	2.6	0.1069
Grade
I + II	3	3	0	> 0.99
III + IV	10	10	0	> 0.99
Pre-treatment status
Locally advanced + metastatic	1	7	6.5	0.0108^a
Local recurrence + Recurrence with distant metastasis	12	6	6.5	0.0108^a

^aP < 0.05.

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Table 2 Parameters for the clonogenic formation assay of irradiated TE-1 and KYSE-30 cells

	NC	siSNAI1	SER
TE-1
D0	1.954	1.642	1.19
n	1.464	1.403	1.19
KYSE-30
D0	2.955	2.457	1.20
n	1.193	1.129	1.20

siSNAI1: Small interfering Snail family transcriptional repressor 1; SER: Sensitization enhancement ratio; NC: Negative control.

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Citation: Lv XL, Peng QL, Wang XP, Fu ZC, Cao JP, Wang J, Wang LL, Jiao Y. Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study. World J Gastrointest Oncol 2025; 17(4): 97644
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/97644.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.97644