MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma

doi:10.4251/wjgo.v17.i4.102084

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Apr 15, 2025 (publication date) through Nov 3, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 102084
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.102084

Table 1 Correlation between MEX3A expression and clinical parameters in hepatocellular carcinoma

Parameters	MEX3A expression
Parameters		n = 26	Low (9)	High (17)	P value
Gender	Male	24	8	16	1
Gender	Female	2	1	1	1
Age (year)	< 65	14	5	9	1
Age (year)	65	12	4	8	1
TNM stage	T1, T2	7	1	6	0.3574
TNM stage	T3, T4	19	8	11	0.3574
HBV	+	16	3	13	0.0461^a
HBV	-	10	6	4	0.0461^a
AFP (ng/mL)	< 400	19	6	13	0.6613
AFP (ng/mL)	400	7	3	4	0.6613
Tumor diameter	< 5	10	7	3	0.0085^a
Tumor diameter	5	16	2	14	0.0085^a
Differentiation	High	9	6	3	0.0277^a
Differentiation	Low	17	3	14	0.0277^a
Hepatocirrhosis	+	16	5	11	0.6924
Hepatocirrhosis	-	10	4	6	0.6924
Vascular invasion	+	21	7	14	1
Vascular invasion	-	5	2	3	1

^aP < 0.05.

AFP: A-fetoprotein; TNM: Tumor node metastasis; HBV: Hepatitis B virus.

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Citation: Ji PX, Zhang P, Zhou HL, Yu H, Fu Y. MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(4): 102084
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/102084.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.102084