To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

Table 1 Core targets and topological parameters

Name	Betweenness	Closeness	Degree
TP53	537.5688911	0.011111111	58
HSP90AA1	411.5735117	0.010416667	53
STAT3	280.5350034	0.010309278	52
AKT1	451.5531513	0.010204082	50
SRC	297.0466707	0.01	49
EGFR	222.7036191	0.00990099	48
CASP3	233.6425731	0.009803922	47
PIK3CA	159.1340985	0.00952381	46
MTOR	126.8320074	0.009433962	43
ESR1	202.0774342	0.009345794	43
HIF1A	109.3920337	0.009259259	41
MDM2	66.2593338	0.008928571	37
MMP9	230.2669059	0.00877193	34
PPARG	269.6527851	0.008695652	33
KDR	65.5729245	0.008130081	26
AR	63.40344608	0.008064516	26

HSP90AA1: Heat shock protein 90 alpha family class A member 1; STAT3: Signal transducer and activator of transcription 3; SRC: Proto-oncogene tyrosine-protein kinase Src; EGFR: Epidermal growth factor receptor; CASP3: Caspase-3; PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; MTOR: Mammalian target of rapamycin; ESR1: Estrogen receptor 1; HIF1A: Hypoxia inducible factor 1 subunit alpha; MDM2: Murine double minute 2; MMP9: Matrix metallopeptidase 9; PPARG: Peroxisome proliferator activated receptor gamma; KDR: Kinase insert domain receptor; AR: Androgen receptor.

Table 2 Docking scores of tetrahydrocurcumin with core target molecules

Name	PDB ID	Target protein scoring, total score
PIK3CA	5DXT	9.2428
KDR	2XIR	9.1786
EGFR	3POZ	9.0041
MMP9	6ESM	8.7419
HSP90AA1	1BYQ	8.5337
STAT3	5AX3	7.9753
PPARG	3B1M	7.9106
MTOR	4DRI	7.8581
AR	1T65	7.6085
AKT1	4GV1	6.6415
TP53	1XQH	6.5781
CASP3	1NMS	6.2940
MDM2	4HG7	6.1486
ESR1	3CBP	5.9387
HIF1A	6GMR	5.6041
SRC	1O41	4.2536

PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; KDR: Kinase insert domain receptor; EGFR: Epidermal growth factor receptor; MMP9: Matrix metallopeptidase 9; HSP90AA1: Heat shock protein 90 alpha family class A member 1; STAT3: Signal transducer and activator of transcription 3; PPARG: Peroxisome proliferator activated receptor gamma; MTOR: Mammalian target of rapamycin; AR: Androgen receptor; CASP3: Caspase-3; MDM2: Murine double minute 2; ESR1: Estrogen receptor 1; HIF1A: Hypoxia inducible factor 1 subunit alpha; SRC: Proto-oncogene tyrosine-protein kinase Src.