Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

Table 1 Statistics of the top 10 most prolific institutions in the study of gastrointestinal tumor organoids

Rank	Affiliations	Country	Centrality	Publications
1	Helmholtz Association	Germany	0.04	93
2	Utrecht University	Netherlands	0.03	85
3	Utrecht University Medical Center	Netherlands	0.03	81
4	German Cancer Research Center (DKFZ)	Germany	0.02	75
5	Hubrecht Institute (KNAW)	Netherlands	0.07	67
6	Royal Netherlands Academy of Arts & Sciences	Netherlands	0.06	66
7	Harvard University	United States	0.01	53
8	University of California System	United States	0.13	49
9	UDICE-French Research Universities	France	0.04	43
10	Sun Yat-sen University	China	0.11	40

Table 2 Statistics on the number of publications and total citations from the top ten journals in the field of gastrointestinal tumor organoids

Rank	Sources	Articles	Zone	H-index	Cited sources	Citations
1	Cancers	83	Q2	18	Nature	5009
2	Gastroenterology	51	Q1	28	Cell	4009
3	Oncogene	40	Q1	17	Proceedings of the National Academy of Sciences of the United States of America	2435
4	Cancer Research	37	Q1	19	Gastroenterology	2399
5	Scientific Reports	36	Q2	15	Cancer Research	2340
6	Nature Communications	35	Q1	16	Science	2225
7	Frontiers in Oncology	33	Q2	9	Nature Medicine	1969
8	Cellular and Molecular Gastroenterology and Hepatology	24	Q1	12	Cell Stem Cell	1807
9	Journal of Experimental & Clinical Cancer Research	23	Q1	12	Nature Communications	1507
10	Cancer Science	21	Q2	7	Clinical Cancer Research	1490

Table 3 Statistics on the number of publications and citations of top 10 authors in the field of gastrointestinal tumor organoids

Rank	Authors	Documents	Cited author	Citations
1	Hans Clevers	51	Toshiro Sato	1014
2	Toshiro Sato	20	Nick Barker	467
3	David Tuveson	15	Marc van der Wetering	410
4	Onno Kranenburg	15	Jarno Drost	387
5	Masanobu Oshima	15	Sylvia F Boj	320
6	Owen J Sansom	14	Masayuki Fujii	307
7	Van der Laan	14	Meritxell Huch	289
8	Monique Verstegen	13	Georgios Vlachogiannis	262
9	Deniel Stange	13	Herve Tiriac	226
10	Emile Voest	13	Rebecca L Siegel	226

Table 4 Trending topic in the field of gastrointestinal tumor organoids between 2012 and 2022

Item	Frequency	Year_q1	Year_med	Year_q3
Negative regulator	7	2012	2014	2020
Organotypic culture	6	2016	2016	2019
Wnt receptors	6	2015	2016	2018
Ductal pancreatic-cancer	8	2017	2017	2018
Paneth cells	6	2015	2017	2020
Adenomas	5	2017	2017	2021
Lgr5	22	2016	2018	2019
Crypt	20	2017	2018	2020
Epithelium	19	2016	2018	2019
In-vitro expansion	69	2018	2019	2021
Beta-catenin	58	2017	2019	2021
Tumorigenesis	51	2017	2019	2021
Expression	296	2019	2020	2022
Stem-cells	272	2019	2020	2022
In-vitro	227	2018	2020	2022
Cancer	156	2019	2021	2022
Cells	148	2019	2021	2022
Activation	132	2019	2021	2022
Patient-derived organoids	31	2021	2022	2022
Metabolism	28	2018	2022	2022

Table 5 Top ten articles with the strongest citation bursts

Strength	Tittle	Source	First author	Impact index per article1
46.9	Prospective derivation of a living organoid biobank of colorectal cancer patients	Cell	Marc van de Wetering	183.5
34.04	Organoid models of human and mouse ductal pancreatic cancer	Cell	Sylvia F Boj	132.1
31.15	Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium	Gastroenterology	Toshiro Sato	179.2
21.96	Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids	Nature Medicine	Mami Matano	81.2
20.92	Sequential cancer mutations in cultured human intestinal stem cells	Nature	Jarno Drost	76.6
17	Deterministic progenitor behavior and unitary production of neurons in the neocortex	Cell	Peng Gao	30.7
16.73	Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients	Cell Stem Cell	Gerald Schwank	89.8
16.27	Comprehensive molecular characterization of human colon and rectal cancer	Nature	Cancer Genome Atlas Network	507.3
16.04	Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture	Nature medicine	Xingnan Li	29.5
16.02	Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases	Proceedings of the National Academy of Sciences of the United States of America	Fleur Weeber	31.1

¹The impact index per article is presented based on Reference Citation Analysis.