Correlation analysis of interstitial maturity and prognosis of colorectal cancer: Meta-analysis

Table 1 Basic characteristics of included studies and Newcastle-Ottawa Scale scores (mean ± SD)

Ref.	Time	Research type	Cases	Gender (male/female)	Age (yr)	Stage	Follow-up time (months)	NOS score
Ueno et al[5]	2002	Cohort study	627	393/234	60.3 ± 12	Ⅰ-Ⅲ	153 (80-267)	6
Ueno et al[6]	2004	Cohort study	862	NA	NA	Ⅰ-Ⅲ	140	6
Wu et al[7]	2014	Cohort study	412	NA	61.4 ± 12	Ⅳ	61 (11-188)	7
Ueno et al[8]	2015	Cohort study	880	512/368	62.9 ± 13	Ⅱ-Ⅲ	68	8
Ueno et al[8]	2015	Cohort study	474	268/206	66.3 ± 13	Ⅱ-Ⅲ	68	6
Ueno et al[9]	2017	Cohort study	821	484/337	66.2 ± 12	Ⅱ-Ⅲ	59 (1-86)	7
Wu et al[10]	2018	Cohort study	466	264/202	59.9 ± 13	Ⅲ	59 (45-144)	7
Wu et al[10]	2018	Cohort study	432	247/185	65.1 ± 12	Ⅲ	58 (1-87)	8
Shin et al[11]	2019	Cohort study	151	88/63	63.2 ± 11	Ⅰ-Ⅳ	56	6
Konishi et al[12]	2018	Cohort study	851	407/444	66 ± 14	Ⅰ-Ⅲ	58	6
Nearchou et al[13]	2019	Cohort study	283	184/99	62.3 ± 11	Ⅱ	NA	6
Nearchou et al[13]	2019	Cohort study	163	87/76	63 ± 12	Ⅱ	NA	7
Ueno et al[14]	2019	Cohort study	679	400/279	64.0 ± 12	Ⅱ	91	8
Ueno et al[14]	2019	Cohort study	446	267/179	67.0 ± 12	Ⅱ	58	8
González et al[15]	2020	Cohort study	342	179/163	65.2 ± 12.6	Ⅰ-Ⅲ	NA	8
Hacking et al[16]	2020	Cohort study	234	111/118	64 ± 13	I-Ⅲ	NA	6
Ao et al[17]	2020	Cohort study	363	209/154	66.6 ± 12	Ⅲ	61 (1-136)	8
Gonzalez et al[18]	2021	Cohort study	372	189/183	65.7 ± 12.9	Ⅰ-Ⅲ	62 (1-170)	6
Ueno et al[19]	2021	Cohort study	991	601/390	65.5 ± 12.2	Ⅱ	69.7 (2.1-105.6)	7

NOS: Newcastle-Ottawa Scale.

Table 2 Meta-regression analysis of recurrence survival and overall survival

Interstitial maturity	Heterogeneous factor	Relapse free survival		Overall survival rate
		Coefficient	P value	Coefficient	P value
Immaturity	Age	0.098	0.8	0.06	0.93
	Region (Europe and America/Asia)	0.084	0.81	0.63	0.18
	Gender (male/female)	0.05	0.93	0.46	0.21
	Stage (Ⅰ-Ⅱ/Ⅲ-Ⅳ)	-0.73	0.16	-0.5	0.39
	Tumor site (node/rectum)	0.68	0.14	0.46	0.54
	Degree of differentiation (high/medium/low)	-0.02	0.95	-0.74	0.49