Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

Table 1 Comparison of baseline data of rectal carcinoma patients with different T stages

Factors	Low stage group (n = 62)	High stage group (n = 42)	P value
Age (yr)			0.474
≥ 60	34	26
< 60	28	16
Sex			0.636
Male	34	25
Female	28	17
BMI (kg/m2)			0.755
≥ 25	16	12
< 25	46	30
Tumor site			0.991
Upper	21	14
Middle	17	12
Lower	24	16
Tumor type			0.854
Protruded	8	7
Ulcerative	44	29
Infiltrating	10	6
Differentiation degree			0.786
Moderate-high differentiation	40	26
Low differentiation	22	16

BMI: Body mass index.

Table 2 Comparison of baseline data of patients with different differentiation degrees

Factors	M + H group (n = 66)	L group (n = 38)	P value
Age (yr)			0.703
≥ 60	39	21
< 60	27	17
Sex			0.855
Male	37	22
Female	29	16
BMI (kg/m2)			0.572
≥ 25	19	9
< 25	47	29
Tumor site			1.069
Upper	23	12
Middle	20	9
Lower	23	17
Tumor type			0.797
Protruded	10	5
Ulcerative	47	26
Infiltrating	9	7
T staging			0.786
T1-T2	40	22
T3-T4	26	16

M+H: Modern + high; L: Low; BMI: Body mass index.

Table 3 Receiver operating characteristic curve analysis of various parameters

Diagnostic variable	AUC	95%CI	Cut-off	Sensitivity	Specificity	Youden index
T stage
Ktrans	0.638	0.532-0.745	0.26	62.90%	59.52%	22.43%
Ve	0.695	0.595-0.794	0.45	40.32%	92.86%	33.18%
DCE-MRI parameters	0.742	0.646-0.837	0.68	53.23%	92.86%	46.08%
Differentiation degree
Ktrans	0.672	0.549-0.795	0.29	87.88%	57.90%	45.77%
Ve	0.725	0.626-0.824	0.49	75.76%	63.16%	38.92%
DCE-MRI parameters	0.769	0.677-0.861	0.35	78.79%	65.79%	44.58%

AUC: Area under the curve; Ktrans: Volume transfer constant; Ve: Extravascular extracellular volume fraction; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging.

Table 4 Receiver operating characteristic curve analysis of various parameters

Diagnostic variable	AUC	95%CI	Cut-off	Sensitivity	Specificity	Youden index
T stage
CA19-9	0.773	0.684-0.863	23.63	53.23%	100.00%	53.23%
CA125	0.802	0.716-0.888	66.90	67.74%	90.48%	58.22%
DCE-MRI parameters + tumor markers	0.836	0.756-0.916	0.93	72.58%	95.24%	67.82%
Differentiation degree
CA19-9	0.834	0.758-0.909	27.49	81.82%	68.42%	50.24%
CA125	0.796	0.711-0.881	66.82	62.12%	89.47%	51.60%
DCE-MRI parameters + tumor markers	0.946	0.903-0.990	0.76	87.88%	97.37%	85.25%

AUC: Area under the curve; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging; CA19-9: Carbohydrate antigen 19-9; CA125: Carbohydrate antigen 125.

Table 5 Delong test of the areas under the curve of DCE-MRI parameters and tumor markers in distinguishing T staging and differentiated degree

Test results	Z value	P value	Difference in AUC	Standard error difference	95%CI
					Lower bound	Upper bound
T stage
CA199-CA125	-1.452	0.146	-0.029	0.293	-0.068	0.01
CA199 - DCE-MRI parameters + tumor markers	7.616	< 0.001	0.609	0.299	0.453	0.766
CA125- DCE-MRI parameters + tumor markers	7.856	< 0.001	0.638	0.296	0.479	0.797
Differentiation degree
CA199-CA125	0.617	0.537	0.038	0.287	-0.082	0.157
CA199- DCE-MRI parameters + tumor markers	14.913	< 0.001	0.780	0.248	0.677	0.882
CA125- DCE-MRI parameters + tumor markers	13.382	< 0.001	0.742	0.257	0.633	0.851

AUC: Area under the curve; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging; CA19-9: Carbohydrate antigen 19-9; CA125: Carbohydrate antigen 125.