Mu RQ, Lv JW, Ma CY, Ma XH, Xing D, Ma HS. Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis. World J Gastrointest Oncol 2024; 16(5): 1796-1807 [PMID: 38764818 DOI: 10.4251/wjgo.v16.i5.1796]
Corresponding Author of This Article
Hou-Sheng Ma, BMed, Doctor, Department of Radiology, Yantai Yuhuangding Hospital, No. 20 Yuhuangding East Road, Zhifu District, Yantai 264000, Shandong Province, China. mahousheng1971@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ren-Qi Mu, Department of Radiology, Yantai Mountain Hospital, Yantai 264001, Shandong Province, China
Jun-Wei Lv, Dong Xing, Hou-Sheng Ma, Department of Radiology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong Province, China
Cai-Yun Ma, Department of Gynaecology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong Province, China
Xiao-Hui Ma, The First Clinical Medical College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Co-first authors: Ren-Qi Mu and Jun-Wei Lv.
Author contributions: Mu RQ and Lv JW contributed equally to this work and are co-first authors; Mu RQ, Lv JW and Ma HS designed the research and wrote the first manuscript; Mu RQ, Lv JW, Ma CY, Ma XH, Xing D and Ma HS contributed to conceiving the research and analyzing data; Mu RQ and Lv JW conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Yantai Yuhuangding Hospital (2023-297).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hou-Sheng Ma, BMed, Doctor, Department of Radiology, Yantai Yuhuangding Hospital, No. 20 Yuhuangding East Road, Zhifu District, Yantai 264000, Shandong Province, China. mahousheng1971@163.com
Received: December 12, 2023 Peer-review started: December 12, 2023 First decision: January 2, 2024 Revised: January 15, 2024 Accepted: February 29, 2024 Article in press: February 29, 2024 Published online: May 15, 2024 Processing time: 149 Days and 5.2 Hours
ARTICLE HIGHLIGHTS
Research background
Rectal carcinoma (RC) is a globally prevalent fatal tumor, and its early diagnosis and staging are crucial. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters and serum levels of carbohydrate antigen 19-9 (CA19-9) and CA125 have shown potential diagnostic value in many diseases, but their roles in the assessment of T stage and degree of differentiation in RC remain unclear.
Research motivation
The motivation of this study is to clarify the effectiveness of DCE-MRI parameters and serum levels of CA19-9 and CA125 in assessing the T stage and degree of differentiation in RC. We hope that through this study, we can provide clinicians with a reliable tool for more accurate diagnosis and treatment of RC.
Research objectives
The objective of this study was to investigate the application of DCE-MRI parameters and serum levels of CA19-9 and CA125 in evaluating the T stage and degree of differentiation of RC to improve the diagnostic accuracy and treatment effect of RC.
Research methods
We conducted a retrospective study on eligible patients with RC and collected and analyzed the DCE-MRI parameters and serum levels of CA19-9 and CA125. We then evaluated their predictive ability for T stage and degree of differentiation of RC using statistical models.
Research results
Our research results show that DCE-MRI parameters and serum levels of CA19-9 and CA125 have significant predictive abilities and may improve RC-related diagnostic accuracy.
Research conclusions
DCE-MRI parameters and serum levels of CA19-9 and CA125 have significant value in assessing the T stage and degree of differentiation of RC and can be used to help physicians provide more personalized treatment plans, improving patient prognosis.
Research perspectives
Future research might further explore the application of these tools in a broader cohort of patients with RC as well as how they could be combined with other potential biomarkers and imaging parameters to provide a more comprehensive framework for RC assessment.
