Retrospective Study
Copyright ©The Author(s) 2023.
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1475-1485
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1475
Table 1 Comparison of general data between the two groups
GroupnGender (n)
Age (yr)Smoking history (case)
Alcohol history (n)
Male
Female
Yes
No
Yes
No
Gastric cancer group87464159.11 ± 6.0252355631
Control group80413958.94 ± 5.7643374535
χ20.0440.1860.6161.149
P value0.8340.8530.4330.284
Table 2 Comparison of serum carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 levels between the two groups
Group
n
CEA (ng/mL)
CA199 (U/mL)
CA724 (U/mL)
Gastric cancer group8723.69 ± 4.8352.75 ± 8.5241.32 ± 6.53
Control group802.58 ± 0.794.62 ± 1.495.10 ± 1.27
t value38.61149.81948.759
P value< 0.001< 0.001< 0.001
Table 3 Comparison of serum carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 levels in patients with different stages of gastric cancer
Group
n
CEA (ng/mL)
CA199 (U/mL)
CA724 (U/mL)
Gastric cancer stage I group2018.05 ± 4.1646.31 ± 6.7834.29 ± 5.46
Gastric cancer stage II group2321.43 ± 4.22a50.25 ± 5.27a39.41 ± 5.89a
Gastric cancer stage III group2825.58 ± 5.37a,b54.33 ± 7.64a,b43.68 ± 6.03a,b
Gastric cancer stage IV group1630.68 ± 4.83a,b,c61.63 ± 8.11a,b,c48.72 ± 6.95a,b,c
F value29.48221.70925.139
P value< 0.001< 0.001< 0.001
Table 4 Comparison of the positive rates of single and combined detection of carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in patients with gastric cancer
Indicators
Number of positive tests
Positive rate (%)
CEA4652.87
CA1994855.17
CA7246271.26a,b
Combined8395.40a,b,c
Table 5 Comparison of positive rates of single and combined detection of serum carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in patients with different stages of gastric cancer, n (%)
Indicators
Gastric cancer stage I
Gastric cancer stage II
Gastric cancer stage III
Gastric cancer stage IV
CEA45 (51.72)44 (50.57)47 (54.02)48 (55.17)
CA19942 (48.28)48 (55.17)50 (57.47)52 (59.77)
CA72459 (67.82)60 (68.97)64 (73.56)65 (74.71)
Combined78 (89.66)a,b,c81 (93.10)a,b,c86 (98.85)a,b,c87 (100.00)a,b,c
Table 6 Relationship between serum carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 levels and clinicopathology in patients with gastric cancer
Clinical pathology

n
CEA (ng/mL)
CA199 (U/mL)
CA724 (U/mL)
GenderMale4623.42 ± 4.6552.49 ± 7.8341.29 ± 6.18
Female4123.99 ± 5.1253.04 ± 7.6741.35 ± 6.22
Age< 45 years old6020.47 ± 8.5349.18 ± 9.1339.02 ± 6.45
≥ 45 years old2730.85 ± 8.77a60.68 ± 8.85a46.43 ± 6.76a
Smoking historyYes5223.51 ± 4.4352.66 ± 8.4141.57 ± 6.17
No3523.96 ± 4.5052.88 ± 8.3540.95 ± 6.03
Alcohol historyYes5623.49 ± 4.8152.69 ± 7.4141.30 ± 5.94
No3124.05 ± 4.8752.86 ± 9.0341.36 ± 6.12
TNM stagingPhase I-II4321.02 ± 4.6548.63 ± 8.7537.25 ± 6.88
Phase III-IV4426.30 ± 4.72b56.78 ± 9.24b45.30 ± 7.13b
lymphatic metastasisNo4520.83 ± 4.2346.16 ± 7.3638.11 ± 6.59
Yes4226.75 ± 4.88c59.81 ± 8.48c44.76 ± 6.13c
Tumor diameter< 5 cm4919.61 ± 4.6747.02 ± 8.5535.26 ± 6.62
≥ 5 cm3828.95 ± 5.01d60.14 ± 9.31d49.13 ± 6.89d
Table 7 Comparison of serum carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 levels before and after operation in 87 patients with gastric cancer
Group
n
CEA (ng/mL)
CA199 (U/mL)
CA724 (U/mL)
Before procedure8733.11 ± 3.6357.72 ± 6.6431.23 ± 3.45
After procedure877.24 ± 1.8114.23 ± 2.374.12 ± 1.12
t value59.48857.53669.712
P value< 0.001< 0.001< 0.001