Copyright
©The Author(s) 2023.
World J Gastrointest Oncol. May 15, 2023; 15(5): 843-858
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.843
Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.843
Table 1 Demographics and clinicopathologic characteristics of patients with invasive intraductal papillary neoplasm of the bile duct, n (%)
| Variable | Total (n = 1635) | Subtype 1 (mucin) | Subtype 2 (non-mucin) |
| Age at diagnosis, yr | n = 926 | n = 709 | |
| < 68 | 796 (48.7) | 464 (50.1) | 332 (46.8) |
| ≥ 68 | 839 (51.3) | 462 (49.9) | 377 (53.2) |
| Sex | |||
| Male | 896 (54.8) | 504 (56.3) | 392 (55.3) |
| Female | 739 (45.2) | 422 (45.6) | 317 (44.7) |
| Race | |||
| White | 1278 (78.2) | 741 (80.0) | 537 (75.7) |
| Black | 116 (7.1) | 67 (7.2) | 49 (7.1) |
| Others | 241 (14.7) | 118 (12.7) | 123 (17.3) |
| THM 7/CSv0204+ schema | |||
| Liver | 100 (6.1) | 90 (9.7) | 10 (1.4) |
| Intrahepatic bile | 99 (6.1) | 87 (9.4) | 12 (1.7) |
| Perihilar bile | 600 (36.6) | 304 (32.8) | 296 (41.7) |
| Distal bile | 53 (3.2) | 27 (2.9) | 26 (3.7) |
| Pancreaticobiliaryampulla | 783 (47.9) | 418 (45.1) | 365 (51.5) |
| SEER historic stage | |||
| Localized | 401 (24.5) | 130 (14) | 271 (38.2) |
| Regional | 814 (49.8) | 482 (52.1) | 332 (46.8) |
| Distant | 317 (19.4) | 259 (28) | 58 (8.2) |
| Unstaged | 103 (6.3) | 55 (5.9) | 48 (6.8) |
| Grade | |||
| Well (I) | 373 (22.8) | 119 (12.9) | 254 (35.8) |
| Moderately (II) | 532 (32.5) | 310 (33.5) | 222 (31.3) |
| Poorly (III) | 227 (13.8) | 176 (19.0) | 51 (7.2) |
| Undifferentiated (IV) | 22 (1.3) | 11 (1.2) | 11 (1.6) |
| Unknown | 481 (29.4) | 310 (33.5) | 171 (24.1) |
| Surgery | |||
| Performed | 982 (60.1) | 483 (52.2) | 489 (70.4) |
| Defined radical surgery | 579 (35.4) | 336 (36.3) | 243 (35.0) |
| Undefined radical surgery | 375 (22.9) | 130 (14.1) | 235 (33.4) |
| Palliative surgery | 28 (1.8) | 17 (1.8) | 11 (2.0) |
| Non | 653 (39.9) | 443 (47.8) | 210 (29.6) |
| Radiatherapy | |||
| Performed | 286 (17.5) | 173 (18.7) | 113 (15.9) |
| Non | 1349 (82.5) | 753 (81.3) | 596 (84.1) |
| Chemotherapy | |||
| Performed | 458 (28.0) | 339 (36.6) | 119 (16.8) |
| Non | 1177 (72.0) | 587 (63.4) | 590 (83.2) |
Table 2 Univariable analysis of factors associated with overall survival and cancer-specific survival
| Variable | Univariate (P value) | |
| Overall survival | Cancer specific survival | |
| Age at diagnosis, yr | 0.000 | 0.030 |
| < 68 | ||
| ≥ 68 | ||
| Sex | 0.785 | 0.355 |
| Male | ||
| Female | ||
| Race | 0.062 | 0.689 |
| White | ||
| Black | ||
| Others | ||
| TNM7/CSv0204+ schema | 0.000 | 0.000 |
| Intrahepata and liver | ||
| Perihilar | ||
| Distal and pancreaticobiliary ampulla | ||
| SEER historic stage | 0.000 | 0.000 |
| Localized | ||
| Regional | ||
| Distant | ||
| Unstaged | ||
| Grade | 0.000 | 0.000 |
| Well | ||
| Moderate | ||
| Poor and undifferentiated | ||
| Unknown | ||
| Classification | 0.000 | 0.000 |
| Mucin | ||
| Non | ||
| Surgery | 0.000 | 0.000 |
| Defined radical surgery | ||
| Undefined radical surgery | ||
| Palliative surgery | ||
| Non | ||
| Radiatheray | 0.909 | 0.222 |
| Performed | ||
| Non | ||
| Chemotherapy | 0.075 | 0.040 |
| Performed | ||
| Non | ||
- Citation: Wu RS, Liao WJ, Ma JS, Wang JK, Wu LQ, Hou P. Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct. World J Gastrointest Oncol 2023; 15(5): 843-858
- URL: https://www.wjgnet.com/1948-5204/full/v15/i5/843.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i5.843