Paired-related homeobox 1 induces epithelial-mesenchymal transition in oesophageal squamous cancer

Table 1 Expression of paired-related homeobox 1 in 100 cases of esophageal cancer and adjacent normal esophageal tissues (λ²-test)

Protein	Esophageal cancer tissues	Esophageal cancer adjacent normal tissues	P value
PRRX1
+	62	43	0.007
-	38	57

PRRX1: Paired-related homeobox 1.

Table 2 Correlation between paired-related homeobox 1 immunostaining and clinicopathologic features in 100 cases of esophageal cancer tissues (λ²-test)

Parameters	n	PRRX1		P value
		+	-
Age (yr)				0.529
< 60	30	20	10
≥ 60	70	42	28
Gender				0.813
Male	67	41	26
Female	33	21	12
Tumor location				0.626
Upper	19	10	9
Middle	60	39	21
Lower	21	13	8
T-stage				0.024
T1-T2	29	13	16
T3-T4	71	49	22
Histologic grade				0.423
Well	17	9	8
Middle	58	35	23
Poor	25	18	7
Lymph node metastasis				0.014
Negative	35	16	19
Positive	65	46	19
pTNM stage				0.009
I	14	5	9
II	26	12	14
III	44	34	10
IV	16	11	5

Both depth of tumor invasion and tumor node metastasis (TNM) stage: According to 2018 TNM classification of malignant tumors by the International Union Against Cancer. TNM: Tumor node metastasis; PRRX1: Paired-related homeobox 1.