Expression and significance of miR-654-5p and miR-376b-3p in patients with colon cancer

Table 1 Association between clinical or pathological factors and miR-654-5p expression levels in colon cancer using data from The Cancer Genome Atlas

	n	MiR-654-5p expression
		low	high	χ2	P value
Age				0.006	0.938
≤ 60	119	59	60
> 60	294	147	147
Gender				0.414	0.520
Female	195	94	101
Male	218	112	106
Race				4.613	0.099
White	202	90	112
African	57	30	27
Asian	11	7	4
Site				0.144	0.931
Ascending	162	81	81
Transverse	36	17	19
Descending	122	62	60
TNM stage				9.759	0.002
I-II	229	130	99
III-IV	184	86	108
Metastasis				5.463	0.019
M0	352	184	168
M1	61	22	39
MiR-376b-3p expression				7.866	0.005
Low	206	117	89
High	207	89	118

Table 2 Association between clinical or pathological factors and miR-376b-3p expression levels in colon cancer using data from The Cancer Genome Atlas

	n	MiR-376b-3p expression
		low	high	χ2	P value
Age				0.087	0.768
≤ 60	119	58	61
> 60	294	148	146
Gender				0.707	0.4
Female	195	93	102
Male	218	113	105
Race				8.274	0.016
White	202	91	111
African	57	20	37
Asian	11	9	2
Site				6.251	0.044
Ascending	162	84	78
Transverse	36	11	25
Descending	122	52	70
TNM stage				4.097	0.043
I-II	229	104	125
III-IV	184	102	82
Metastasis				4.413	0.036
M0	352	168	184
M1	61	38	23
MiR-654-5p expression				7.866	0.005
Low	206	117	89
High	207	89	118

Table 3 Prognosis‑associated clinical characteristics in colon cancer using data from The Cancer Genome Atlas

	Univariate analysis		Multi variate analysis
	P value	HR (95%CI)	P value	HR (95%CI)
Age	0.354	0.806 (0.511-1.272)
Gender	0.575	0.889 (0.588-1.343)
Race	0.671	0.911 (0.592-1.403)
TNM stage	0.000	0.305 (0.200-0.465)	0.002	2.199 (1.323-3.656)
Metastasis	0.000	0.093 (0.048-0.180)	0.000	2.886 (1.739-4.790)
MiR-376b-3p expression	0.007	1.782 (1.173-2.707)	0.012	0.518 (0.339-0.792)
MiR-654-5p expression	0.044	0.655 (0.434-0.989)	0.058	0.725 (0.421-1.372)