Prognostic significance of KIF23 expression in gastric cancer

Table 1 KIF 23 expression in gastric cancer and normal tissues, n (%)

	Cases	KIF23 expression		P value
		Low	High
Cancer	174	30 (17.2)	144 (82.8)	< 0.001
Normal	174	169 (97.1)	5 (2.9)

Table 2 Correlation between KIF23 expression and clinicopathological features in gastric cancer

	n = 174	KIF23 expression		P value
		Low (n = 130)	High (n = 44)
Age (yr)				0.539
≤ 60	90	69	21
> 60	84	61	23
Gender				0.583
Male	129	95	34
Female	45	35	10
Diameter (cm)				0.667
≤ 4	80	61	19
> 4	94	69	25
Differentiation type				0.188
Poor	104	74	30
Non-poor	70	56	14
Borrmann type				0.453
I-II	15	10	5
III-IV	159	120	39
T stage				0.051
T1-T3	56	47	9
T4	118	83	35
N stage				0.0471
N0	61	51	10
N1-N3	113	79	34
TNM stage				0.0221
I-IIA	37	33	4
IIB-IIIC	137	97	40

¹Significant difference.

Table 3 Prognostic factors in Cox’s proportional hazards model in gastric cancer (n = 174)

Variable	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age (yr): > 60 vs ≤ 60	0.822	0.555-1.217	0.328
Gender: Male vs female	1.297	0.838-2.008	0.243
Diameter: > 4 cm vs ≤ 4 cm	0.616	0.350-1.084	0.093
Differentiation type: Poor vs non-poor	0.552	0.336-0.906	0.0191	0.840	0.502-1.404	0.505
Borrmann type: I-IV	1.703	1.109-2.617	0.0151	1.410	0.916-2.169	0.119
T stage: T1-T4	1.546	1.141-2.095	0.0051	1.310	0.858-2.000	0.210
N stage: N0-N3	1.693	1.424-2.013	0.0001	1.869	1.356-2.575	0.0001
TNM stage: I-IIIC	2.410	1.637-3.547	0.0001	0.595	0.259-1.366	0.221
KIF23 expression: High-level vs low-level	1.064	1.006-1.126	0.0291	1.069	1.006-1.135	0.0301

¹Significant difference.

Table 4 Correlation between KIF23 mRNA expression and gastric cancer patients in Kaplan–Meier database

Variable	Cases	HR (95%CI)	P value
Overall patients	593	1.64 (1.32-2.02)	3.9e-061
T stage
T2	66	2.05 (0.98-4.26)	0.0501
T3	117	1.83 (1.14-2.94)	0.0121
N stage
N0	38	2.78 (0.88-8.73)	0.069
N1 + N2 + N3	175	1.33 (0.92-1.94)	0.130
M stage
M0	186	1.74 (1.17-2.59)	0.00531
M1	31	0.49 (0.19-1.23)	0.120
Gender
Male	360	2.07 (1.60-2.69)	1.9e-081
Female	138	1.50 (0.95-2.37)	0.078
Differentiation
Well	32	0.41 (0.16-1.08)	0.062
Moderate	67	0.75 (0.38-1.48)	0.400
Poor	165	1.67 (1.12-2.49)	0.0121
Lauren classification
GITA	179	0.76 (0.52-1.11)	0.15
GDA	106	2.05 (1.23-3.39)	0.00471
GMA	25	0.22 (0.03-1.68)	0.11

¹Significant difference.