Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1104
Peer-review started: April 14, 2020
First decision: May 15, 2020
Revised: May 29, 2020
Accepted: August 15, 2020
Article in press: August 15, 2020
Published online: October 15, 2020
Processing time: 183 Days and 3.2 Hours
Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of KIF23 expression can cause mitotic arrest. By querying the Oncomine database, differences in expression between tumor and normal tissues can be determined.
We detected the expression level of KIF23 protein in gastric cancer (GC) and adjacent normal tissues, and analyzed the association between KIF23 protein expression and clinicopathological factors.
This study aimed to study the expression and prognostic significance of KIF23 in GC.
Immunohistochemistry was used to compare the expression of KIF23 in GC and normal gastric tissues. The data on the expression and prognosis of KIF23 in GC were mined using Oncomine and Kaplan–Meier plotter database.
Compared with normal gastric tissues, KIF23 expression was increased in GC tissues, and correlated with T, N, and tumor–node–metastasis stages. Survival analysis showed that patients with high expression of KIF23 had a poor overall survival. The prognostic survival indicators worsened in patients with T2 and T3 poorly differentiated adenocarcinoma with high expression of KIF23.
KIF23 is highly expressed in GC, and it is associated with a poor prognosis of GC patients.
We found that KIF23 overexpression in gastric cancer tissues is related to prognosis. Use of a database for large sample analysis can avoid errors caused by a small sample size and provide an important theoretical basis for clinical treatment. The specific mechanism of KIF23 in the development of gastric cancer needs further study.