Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases

Figure 1 Heamatoxylin and eosin stained sections showing the tumor itself is composed of small uniform tumor nests of goblet cells and signet ring cells, often arranged in a microglandular fashion and sometimes accompanied by extracellular mucus (A: H and E; × 200) and adenocarcinoid tumor of goblet cell type showing positivity intra- and extra-cellular mucin deposition (B: Mucicarmine; × 400). H and E: Heamatoxylin and eosin.

Figure 2 Tumor cells exhibit strong immunoreactivity for epithelial membrane antigen (A) and for neuroendocrine markers (B). A: EMA, IHC; × 200; B: Chromogranin-A, IHC; × 200.

Figure 3 Adenocarcinoid tumor of goblet cell type tumor showing strong acute appendicitis findings (H and E; × 100).

Figure 4 PAS-Alcian Blue pH 2. 5 deposition were detected in the tumor tissue (PAS/AB; × 200).

Figure 5 Adenocarcinoid tumor of goblet cell type showing positivity for immunoreactivity monoclonal carcinoembryonic antigen (IHC; × 200).

Figure 6 Heamatoxylin and eosin stained sections showing the tumor was wide, eosinophilic, had granular cytoplasm forming small nests and cords, and was characterized by small uniform nests with eccentric nuclei, signet-ring with micro glandular development and cells in goblet cell appearance (H and E; × 200).

Figure 7 In the immunohistochemical studies neuroendocrine cell component markers, synaptophysin and chromogranin-A strong focal positivity were detected in the tumor (IHC; × 200).