Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection

doi:10.4251/wjgo.120469

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 120469
Published online Jul 15, 2026. doi: 10.4251/wjgo.120469

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Figure 1 Survival in cholangiocarcinoma with respect to ARID5B rs10730055. Survival figures after curative-intent surgery for intrahepatic cholangiocarcinoma (iCCA) and perihilar cholangiocarcinoma (pCCA) are displayed. A-C: The median recurrence-free survival (RFS) (A), overall survival (OS) (B) and cancer-specific survival (CSS) (C) after resection for iCCA were 13 months, 30 months and 28 months for the CC/CA genotype and 8 months, 16 months, 12 months for the AA genotype; D-F: The median RFS (D), OS (E) and CSS (F) after resection for pCCA were 52 months, 65 months and 50 months for the CC/CA genotype and 15 months, 19 months, 14 months for the AA genotype. iCCA: Intrahepatic cholangiocarcinoma; pCCA: Perihilar cholangiocarcinoma.

Citation: Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/120469.htm
DOI: https://dx.doi.org/10.4251/wjgo.120469

Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469 [DOI: 10.4251/wjgo.120469]

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