Translational implications of the MAZ/UHRF1/ECRG4 axis in metastatic colorectal carcinoma

Figure 1 Metastatic outcomes following activation of the Myc-associated zinc finger protein-Ubiquitin-like with PHD and RING finger domains 1-esophageal cancer-related gene 4 axis. Myc-associated zinc finger protein binds to the Ubiquitin-like with PHD and RING finger domains 1 promoter, activating transcription and downstream protein synthesis. Ubiquitin-like with PHD and RING finger domains 1, directly or indirectly, then leads to hypermethylation of esophageal cancer-related gene 4, thereby decreasing its expression. This culminates in a metastatic transition governed by epithelial-mesenchymal transition-induced changes within the tumor microenvironment. ECRG4: Esophageal cancer-related gene 4; EMT: Epithelial-mesenchymal transition; MAZ: Myc-associated zinc finger protein; UHRF1: Ubiquitin-like with PHD and RING finger domains 1.