Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma

doi:10.4251/wjgo.v18.i1.114339

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Jan 15, 2026 (publication date) through Jan 12, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114339
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114339

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Figure 1 Hepatocellular carcinoma at the edge of the left lobe in patient with. A: Laparoscopic view; B: Indocyanine green-window view.

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Figure 2 Indocyanine green fluorescence patterns and microinvasive components. A: Hepatocellular carcinoma with vascular micro-invasion, indocyanine green (ICG)-window view showed more nodules with intense ICG fluoresce; B: Hepatocellular carcinoma with microinvasive components due to periductal infiltrating growth, which showed a homogeneous and intense area of neoplastic tissue with partial fluorescence around the peritumoral area (intensity maps of IMAGE1 S^™ Rubina^®, Karl Storz Endoscope).

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Figure 3 Indocyanine green evolution timeline. ICG: Indocyanine green; MILS: Minimally invasive liver surgery; FDA: Food and Drug Administration.

Citation: Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339
URL: https://www.wjgnet.com/1948-5204/full/v18/i1/114339.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i1.114339