Basic Study
Copyright ©The Author(s) 2025.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 104860
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.104860
Figure 1
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Figure 1 Flowchart of participants in the preliminary untargeted metabolomics analysis. GC-MS: Gas chromatography-mass spectrometry; LC-MS: Liquid chromatography-mass spectrometry; MS: Mass spectrometry.
Figure 2
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Figure 2 Volcano plots showing differentially expressed metabolites in gastrointestinal cancers based on gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry analysis. A and B: Colorectal cancer (CRC) vs normal samples; C and D: Gastric cancer (GC) vs normal samples; E and F: CRC vs GC samples. VIP: Variable Importance of Projection.
Figure 3
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Figure 3 Heatmap of differentially expressed metabolites analyzed by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. A: Colorectal cancer (CRC) vs normal samples; B: Gastric cancer (GC) vs normal samples; C: CRC vs GC samples.
Figure 4
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Figure 4 Heatmap exhibiting the correlation between differentially expressed metabolites and the clinical parameters of patients with colorectal cancer and gastric cancer. BMI: Body mass index; RBC: Red blood cell count; WBC: White blood cell count; NEU: Neutrophil count; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; Scr: Serum creatinine; BUN: Blood urea nitrogen; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; AFP: Α-fetoprotein.
Figure 5
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Figure 5 Venn diagram showing the overlap of differentially expressed metabolites between colorectal cancer and gastric cancer. CRC: Colorectal cancer; GC: Gastric cancer.
Figure 6
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Figure 6 Metabolic pathway enrichment analysis in colorectal cancer vs normal controls based on gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. A: Pathway enrichment map highlighting key metabolic pathways; B: Bubble plot.
Figure 7
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Figure 7 Metabolic pathway enrichment analysis in gastric cancer vs normal controls based on gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. A: Pathway enrichment map highlighting key metabolic pathways; B: Bubble plot.
Figure 8
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Figure 8 Metabolic pathway enrichment analysis in common metabolites of colorectal cancer and gastric cancer based on gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. A: Pathway enrichment map highlighting key metabolic pathways; B: Bubble plot.