Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors

doi:10.4251/wjgo.v17.i11.109923

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 11

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (17)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-4) series.

Item

Count

PDF

HTML

Figures (1-2)

Tables (1-4)

Sum=14

Nov 15, 2025 (publication date) through Nov 13, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Gastrointest Oncol. Nov 15, 2025; 17(11): 109923
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.109923

Open in New Tab Full Size Figure Download Figure

Figure 1 Molecular regulatory network of Osteopontin in gastrointestinal tumors. OPN: Osteopontin; CD44: Cluster of differentiation 44; PI3K: Phosphoinositide 3-kinases; PIP2: Phosphatidylinositol-4:5-bisphosphate; PIP3: Phosphatidylinositol-3:4:5-trisphosphate; PTEN: Phosphatase and tensin homolog; AKT: Protein kinase B; mTOR: Mammalian target of rapamycin; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; EMT: Epithelial-mesenchymal transition.

Open in New Tab Full Size Figure Download Figure

Figure 2 An illustrative map of the biological functions of Osteopontin. OPN: Osteopontin; TGF-β: Transforming growth factor-beta; MMPs: Matrix metalloproteinases; CAFs: Cancer-associated fibroblasts; CD: Cluster of differentiation.

Citation: Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
URL: https://www.wjgnet.com/1948-5204/full/v17/i11/109923.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i11.109923