Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

Figure 1 A 66-year-old female patient with hepatocellular carcinoma LR-M. A: Contrast-enhanced ultrasound; B: Corresponding time-intensity curve of the lesion derived with VueBox^® software. CEUS: Contrast-enhanced ultrasound.

Figure 2 Time-intensity curve. FT: Fall time; mTTL: Mean transit time local; PE: Peak enhancemetn; RT: Rise time; TI: The point in time when the tangent of WiR intersects the x-axis.; TO: The point in time when the tangent of the maximum decrease intersects the x-axis; TTP: Time to peak; WiAUC: Wash-in area under the curve; WiR: Wash-in rate; WoR: Wash-out rate; WoAUC: Wash-out area under the curve; WiWoAUC: Wash-in and wash-out area under the curve.

Figure 3 Preferred Reporting Items for Systematic Reviews and Meta-analyses study selection flow diagram.

Figure 4 Standardized mean difference of dynamic contrast-enhanced ultrasound parameters. A: Rise time; B: Fall time; C: Mean transit time local; D: Peak enhancement; E: Wash-in rate; F: Wash-in area under the curve; G: Wash-out area under the curve; H: Wash-in and wash-out area under the curve. mTTL: Mean transit time local; PE: Peak enhancement; HCC: Hepatocellular carcinoma; ICC: Intrahepatic cholangiocarcinoma; SD: Standard deviation; WiR: Wash-in rate; WiAUC: Wash-in area under the curve; WiWoAUC: Wash-in and wash-out area under the curve; WoAUC: Wash-out area under the curve.