Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

Figure 1 Survival rate comparison. A and B: Kaplan-Meier overall survival (OS) curves (A) and progression-free survival (PFS) curves (B) in different subgroups of hepatocellular carcinoma (HCC) patients with circulating tumor cell programmed death-ligand 1 (+); C and D:Kaplan-Meier OS curves (A) and PFS curves (B) in different subgroups of HCC patients with neutrophil-to-lymphocyte ratio; E and F: OS curves (A) as well as PFS curves (B) for different subgroups of HCC patients with circulating tumor cell-neutrophil-to-lymphocyte ratio. HR: Hazard ratio; CTC: Circulating tumor cell; PD-L1: Programmed death-ligand 1; NLR: Neutrophil-to-lymphocyte ratio.

Figure 2 Comparison of the area under the time-dependent receiver operating characteristic curve for overall survival prediction. A-C: Comparison of predictive efficacy of circulating tumor cell (CTC)-neutrophil-to-lymphocyte ratio (A), CTC programmed death-ligand 1 (+) (B), and alpha-fetoprotein (C) indicators at 6, 12, and 18 months in hepatocellular carcinoma patients. CTC: Circulating tumor cell; PD-L1: Programmed death-ligand 1; NLR: Neutrophil-to-lymphocyte ratio; AFP: Alpha-fetoprotein; AUC: Area under the curve.