Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer: A meta-analysis

Figure 1 The methods for retrieving the literature.

Figure 2 Reference risk bias assessment.

Figure 3 Summary of risk bias. +: Low risk, -: High risk; ?: Unclear risk.

Figure 4 Forest plot of neoadjuvant chemoradiotherapy vs neoadjuvant chemotherapy in 3-year disease-free survival. A: Randomized controlled trials; B: Case-control studies). 95%CI: 95% confidence interval.

Figure 5 Funnel plot of 3-year disease-free survival. A: Randomized controlled trials; B: Case-control studies. OR: Odds ratio.

Figure 6 Forest plot of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in 5-year disease-free survival. A: Randomized controlled trials; B: Case-control studies. 95%CI: 95% confidence interval.

Figure 7 Funnel plot of 5-year disease-free survival. A: Randomized controlled trials; B: Case-control studies. OR: Odds ratio; RR: Relative risk.

Figure 8 Three-year overall survival rate between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 9 Five-year overall survival rate between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 10  R0 clearance rate between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 11  Postoperative complete response rate between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 12  Postoperative mortality between neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. A: Forest plot; B: Funnel plot. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 13  Cardiac complications. A: Forest plot; B: Funnel plot. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.

Figure 14  Lung complications. A: Forest plot; B: Funnel plot. A: Forest plot; B: Funnel plot. 95%CI: 95% confidence interval; OR: Odds ratio; RCT: Randomized controlled trial; RS: Retrospective study.