KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers

Figure 1 Autotaxin-lysophosphatidic acid axis plays a key role in the pathophysiology of tumor cells. A: The anabolism and catabolism of tumor extracellular lysophosphatidic acid (LPA). Autotaxin/lysophospholipase D catalyzes the generation of LPA from lysophosphatidylcholine (LPC), and lipid phosphate phosphohydrolases promotes LPC hydrolysis; B: LPA activates multiple pathological processes in tumor cells by binding GPRs (lysophosphatidic acid receptors) to promote tumor occurrence and development. LPC: Lysophosphatidylcholine; LPA: Lysophosphatidic acid; ATX: Autotaxin; Edg: Endothelial cell differentiation gene; LPPs: Lipid phosphate phosphohydrolases; LysoPLD: Lysophospholipase D.