KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers

doi:10.4251/wjgo.v14.i8.1388

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1388-1405
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1388

KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers

Shuo Wang, Jiang Chen, Xiao-Zhong Guo

Shuo Wang, Jiang Chen, Xiao-Zhong Guo, Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China

Author contributions: Wang S wrote the original draft; Chen J and Guo XZ contributed to the review and manuscript editing.

Supported by the National Natural Science Foundation of China, No. 81672465; and the Science and Technology Program of Liaoning Province, No. 2019JH8/10300080.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Xiao-Zhong Guo, PhD, Chief Doctor, Chief Physician, Director, Professor, Department of Gastroenterology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110840, Liaoning Province, China. guoxiaozhong1962@126.com

Received: November 11, 2021
Peer-review started: November 11, 2021
First decision: December 27, 2021
Revised: January 6, 2022
Accepted: July 22, 2022
Article in press: July 22, 2022
Published online: August 15, 2022
Processing time: 272 Days and 5.4 Hours

Core Tip

Core Tip: The KAI1/CD82 gene inhibits the metastasis of most tumors and is significantly correlated with their invasion and prognosis. According to our recent pre-experimental results, we speculated that KAI1/CD82 might inhibit the migration and metastasis of cancer cells by regulating autotaxin (ATX)-lysophosphatidic acid (LPA) axis. However, no relevant research has been reported. To clarify the mechanism of ATX-LPA in KAI1/CD82 inhibition of cancer metastasis will provide an important theoretical basis for targeted cancer therapy, and further research is necessary. In this paper, the molecular composition of the KAI1/CD82 gene and ATX-LPA axis, their physiological functions in tumors, and their roles in gastrointestinal cancers and target therapy are reviewed.